Familiäre hämophygozytische Lymphohistiozytose ist eine genetische Erkrankung, deren Locus noch nicht bei allen Untergruppen definiert werden konnte. Die Erkrankung ist durch eine Panzytopenie gekennzeichnet, die sowohl auf eine Phagozytose der Blutzellen wie auch auf eine Histiozytose des Knochenmaks zurückzuführen ist.
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