Die Progression einer rheumatoiden Arthritis kann durch genetische Varianten im IL10-Gen, welches Interleukin 10 kodiert, beeinflusst werden.
1. |
GOWANS JD et. al. (1964) FAMILIAL FACTORS IN RHEUMATOID ARTHRITIS. |
2. |
Tamiya G et. al. (2005) Whole genome association study of rheumatoid arthritis using 27 039 microsatellites. |
3. |
Lundberg K et. al. (2005) Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. |
4. |
Seo SK et. al. (2004) 4-1BB-mediated immunotherapy of rheumatoid arthritis. |
5. |
John S et. al. (2004) Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites. |
6. |
Sakaguchi N et. al. (2003) Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. |
7. |
Tokuhiro S et. al. (2003) An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. |
8. |
Schönland SO et. al. (2003) Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. |
9. |
Vandenbroeck K et. al. (2003) Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. |
10. |
Camps M et. al. (2005) Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. |
12. |
Suzuki A et. al. (2003) Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. |
13. |
Fisher SA et. al. (2003) Meta-analysis of four rheumatoid arthritis genome-wide linkage studies: confirmation of a susceptibility locus on chromosome 16. |
14. |
Nedvetzki S et. al. (2003) A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor. |
15. |
Okamoto K et. al. (2003) Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. |
16. |
Jawaheer D et. al. (2002) Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. |
18. |
Schaller M et. al. (2001) Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human disease. |
19. |
Orozco G et. al. (2009) Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. |
20. |
Ito Y et. al. (2014) Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease. |
21. |
Okada Y et. al. (2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery. |
22. |
Kurreeman F et. al. (2011) Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. |
23. |
Stahl EA et. al. (2010) Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. |
24. |
Kochi Y et. al. (2010) A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. |
25. |
Boilard E et. al. (2010) Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. |
26. |
Raychaudhuri S et. al. (2009) Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. |
27. |
Gregersen PK et. al. (2009) REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. |
28. |
Lard LR et. al. (2003) Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis. |
30. |
Suzuki A et. al. (2008) Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. |
31. |
Raychaudhuri S et. al. (2008) Common variants at CD40 and other loci confer risk of rheumatoid arthritis. |
32. |
Plenge RM et. al. (2007) Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. |
33. |
Thomson W et. al. (2007) Rheumatoid arthritis association at 6q23. |
34. |
Rizzo R et. al. (2006) HLA-G 14-bp polymorphism regulates the methotrexate response in rheumatoid arthritis. |
35. |
Amos CI et. al. (2006) High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33. |
36. |
Seyler TM et. al. (2005) BLyS and APRIL in rheumatoid arthritis. |
37. |
Carlton VE et. al. (2005) PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. |
38. |
et. al. (2010) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. |
39. |
Martínez A et. al. (2008) Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. |
40. |
Vyse TJ et al. (1996) Genetic analysis of autoimmune disease. |
41. |
Sigurdsson S et. al. (2007) Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. |
42. |
Leadbetter EA et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. |
43. |
Mahdi H et. al. (2009) Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. |
44. |
None (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. |
45. |
Kallberg H et. al. (2007) Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. |
46. |
Holm BC et. al. (2001) Rats made congenic for Oia3 on chromosome 10 become susceptible to squalene-induced arthritis. |
47. |
Begovich AB et. al. (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. |
48. |
Remmers EF et al. (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. |
49. |
Kawane K et al. (2006) Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. |
50. |
Bradley DS et. al. (1997) HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis. |
51. |
Nabozny GH et. al. (1996) HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. |
52. |
Robinson JI et. al. (2012) Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis. |
53. |
Yen JH et. al. (2001) Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. |
54. |
Plenge RM et. al. (2007) TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. |
55. |
Stastny P et. al. (1979) Different HLA-D associations in adult and juvenile rheumatoid arthritis. |
56. |
Jawaheer D et. al. (2001) A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. |
57. |
Allcock RJ et. al. (2001) Haplotypic single nucleotide polymorphisms in the central MHC gene IKBL, a potential regulator of NF-kappaB function. |
58. |
Ota M et. al. (2001) A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region. |
59. |
Zanelli E et. al. (2001) The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci. |
60. |
Müller-Ladner U et. al. (2000) Activation of the IL-4 STAT pathway in rheumatoid synovium. |
61. |
Cox A et. al. (1999) Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis. |
62. |
Vingsbo-Lundberg C et. al. (1998) Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. |
63. |
Cornélis F et. al. (1998) New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. |
65. |
Nanki T et. al. (1996) Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins. |
66. |
Feldmann M et. al. (1996) Rheumatoid arthritis. |
67. |
Hasstedt SJ et. al. (1994) HLA-linked rheumatoid arthritis. |
68. |
Lynn AH et. al. (1995) Genetic epidemiology of rheumatoid arthritis. |
69. |
Gregersen PK et. al. (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. |
70. |
Bell AL et. al. (1992) Heredofamilial deficiency of monocyte esterase in patients with rheumatoid arthritis. |
71. |
Weyand CM et. al. (1992) Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis. |
72. |
Raj T et. al. (2014) Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. |
73. | Wikipedia DE (Rheumatoide_Arthritis) |