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Suszeptibilität für Malaria

Malaria ist eine lebensbedrohlich Parasitenerkrankung, die durch Plasmodien hervorgerufen und durch die Anopheles Mücke übertragen wird. Die Ausprägung der Erkrankung wird durch verschiedene genetische Faktoren beeinflusst.

Gliederung

Disposition für Infektionen
Aspergillose-Infektionsanfälligkeit
Familiäre Candidose
HIV-Resistenz
IRAK4-Mangel
Invasive Pneumokokken-Erkrankung
Masern-Infektanfälligkeit
Meningokokken-Infektanfälligkeit
Resistenz gegenüber Trypanosoma brucei
Septischer Schock
Störungen der mRNA-Editiertfunktion
Suszeptibilität für Bakteriämie 1
Suszeptibilität für Malaria
FCGR2A
FCGR2B
TNF
Suszeptibilität für Mykobakteriosen
Suszeptibilität für Pseudomonas-Infektionen
X-chromosomale Suszeptibilität für Mykobakteriosen durch IKBKG-Defekt

Referenzen:

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Kaushansky A et al. (2015) Malaria parasites target the hepatocyte receptor EphA2 for successful host infection.

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Cockburn IA et al. (2004) A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.

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McGuire W et al. (1994) Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

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Knight JC et al. (1999) A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.

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41.

Clatworthy MR et al. (2007) Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

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Willcocks LC et al. (2010) A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

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43.

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44.

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50.

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51.

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53.

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55.

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56.

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57.

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58.

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59.

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61.

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62.

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63.

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64.

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65.

Orphanet article

Orphanet ID 673 external link
66.

OMIM.ORG article

Omim 611162 external link
67.

Wikipedia Artikel

Wikipedia DE (Malaria) external link
Update: 14. August 2020
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