Niedrigaffiner IgG-FcRezeptor 2-a
Das FCGR2A-Gen kodiert eine Komponente eines Immunglobulin-Rezeptors. Genetische Varianten sind für eine Anfälligkeit für systemischen Lupus erythematodes und verschiedene Infektionen verantwortlich.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Sammartino L et al. (1988) Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1.
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2. |
Schuldt K et al. (2010) FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children.
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3. |
Asano K et al. (2009) A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
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4. |
Lu J et al. (2008) Structural recognition and functional activation of FcgammaR by innate pentraxins.
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5. |
Rodrigo WW et al. (2006) Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32).
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6. |
De Rose V et al. (2005) Fcgamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis.
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7. |
Stein MP et al. (2000) C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific.
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8. |
Moser KL et al. (1998) Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees.
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9. |
Salmon JE et al. (1996) Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.
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10. |
Oakey RJ et al. (1992) Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.
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11. |
Hibbs ML et al. (1988) Molecular cloning of a human immunoglobulin G Fc receptor.
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12. |
None (1989) Function and heterogeneity of human Fc receptors for immunoglobulin G.
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13. |
Grundy HO et al. (1989) The polymorphic Fc gamma receptor II gene maps to human chromosome 1q.
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14. |
Peltz GA et al. (1989) Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.
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15. |
Hibbs ML et al. (1985) The mouse Ly-17 locus identifies a polymorphism of the Fc receptor.
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16. |
Qiu WQ et al. (1990) Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination.
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17. |
Lebo RV et al. (1991) Multicolor fluorescence in situ hybridization and pulsed field electrophoresis dissect CMT1B gene region.
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18. |
Machado LR et al. (2012) Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection.
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Update: 14. August 2020