Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Moldiag Erkrankungen Gene Support Kontakt

Tumornekrose-Faktor

Das TNF-Gen kodiert ein proinflammatorisches Zytokin. Varianten dieses Gens werden mit autosomal dominantem Vererbungsmuster mit einer Neigung zu Asthma und Migräne in Zusammenhang gebracht. Weiterhin scheint eine Assoziation mit vaskulärer Demenz und eine Anfäligkeit für Malaria und septischem Schock zu bestehen.

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Forschung Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Vaskuläre Demenz
TNF
Suszeptibilität für Malaria
FCGR2A
FCGR2B
TNF
Migräne
TNF
Septischer Schock
TNF

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107.

Guo R et al. (2008) Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.

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108.

Tay S et al. (2010) Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing.

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110.

Huang MT et al. (2010) Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis.

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111.

Günther C et al. (2011) Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

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112.

Li Z et al. (2014) The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL.

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OMIM.ORG article

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NCBI article

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Wikipedia Artikel

Wikipedia DE (TNFR-Superfamilie) external link
Update: 14. August 2020
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