Enzyme APOBEC-3A
The APOBEC3A gene encodes a protein of the APOBEC family. Enzymes of this family are responsible for mRNA editing. They introduce base exchanges before the protein is translated, which plays an important role in defense of viral infections and lipid metabolism.
Genetests:
Related Diseases:
References:
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Vartanian JP et al. (2008) Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions.
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2. |
Madsen P et al. (1999) Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.
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3. |
Jarmuz A et al. (2002) An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.
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4. |
Bogerd HP et al. (2006) Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.
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5. |
NCBI article
NCBI 200315
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6. |
OMIM.ORG article
Omim 607109
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7. |
Wikipedia article
Wikipedia EN (APOBEC3A)
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Update: Aug. 14, 2020