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Center for Nephrology and Metabolic Disorders
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Migraine

Migraine is a periodic headache that runs in families. Several genetic factors influencing susceptibility have been identified.

Systematic

Hereditary neurological disorders
Alzheimer disease
Arts syndrome
Ataxia-pancytopenia syndrome
Autism
Autosomal dominant cerebellar ataxia, deafness and narcolepsy
Autosomal recessive spastic paraplegia type 44
Brain malformations with urinary tract defects
Brain small vessel disease with hemorrhage
Brunner syndrome
Charcot-Marie-Tooth disease
Congenital insensitivity to pain with anhidrosis
Epilepsy syndrome
Hereditary benign chorea
Hereditary brain tumors
Hereditary distal motor neuron neuropathy type 5A
Hereditary muscle diseases
Hereditary sensory and autonomic neuropathy type 2A
Hereditary sensory neuropathy type 1E
Hypokalemic periodic paralysis 1
Hypomyelinating Leukodystrophy 2
Idiopathic basal ganglia calcification 1
Intellectual disability-severe speech delay-mild dysmorphism syndrome
Migraine
TNF
Nemaline myopathy 5
Porencephaly
Rett syndrome
Severe neonatal-onset encephalopathy with microcephaly
Spastic paraplegia 17 with amyotrophy of hands and feet
Susceptibility to glioma
Tuberous sclerosis complex
Vascular dementia
X-linked syndromic mental retardation 13

References:

1.

Goadsby PJ et al. (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache.

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2.

Anttila V et al. (2013) Genome-wide meta-analysis identifies new susceptibility loci for migraine.

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3.

Karatas H et al. (2013) Spreading depression triggers headache by activating neuronal Panx1 channels.

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4.

Stam AH et al. (2010) Shared genetic factors in migraine and depression: evidence from a genetic isolate.

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5.

Anttila V et al. (2006) Trait components provide tools to dissect the genetic susceptibility of migraine.

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6.

Stewart WF et al. (2006) Familial risk of migraine: variation by proband age at onset and headache severity.

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7.

Ludvigsson P et al. (2006) Migraine with aura is a risk factor for unprovoked seizures in children.

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8.

Scher AI et al. (2006) Migraine and MTHFR C677T genotype in a population-based sample.

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9.

Oterino A et al. (2004) MTHFR T677 homozygosis influences the presence of aura in migraineurs.

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10.

Olesen J et al. (2004) Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.

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11.

Björnsson A et al. (2003) Localization of a gene for migraine without aura to chromosome 4q21.

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12.

None (1965) MIGRAINE AND HEREDITY.

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13.

GOODELL H et al. (1954) Familiar occurrence of migraine headache: a study of heredity.

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14.

Lassen LH et al. (2002) CGRP may play a causative role in migraine.

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15.

Reuter U et al. (2002) Nuclear factor-kappaB as a molecular target for migraine therapy.

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16.

Wessman M et al. (2002) A susceptibility locus for migraine with aura, on chromosome 4q24.

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17.

Kowa H et al. (2000) The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine.

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18.

Gervil M et al. (1999) Migraine without aura: a population-based twin study.

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19.

Ulrich V et al. (1999) Evidence of a genetic factor in migraine with aura: a population-based Danish twin study.

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20.

Ulrich V et al. (1997) Analysis of 31 families with an apparently autosomal-dominant transmission of migraine with aura in the nuclear family.

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21.

Stewart WF et al. (1996) Variation in migraine prevalence by race.

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22.

Russell MB et al. (1995) Inheritance of migraine investigated by complex segregation analysis.

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23.

Russell MB et al. (1993) Familial occurrence of migraine without aura and migraine with aura.

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24.

Glover V et al. (1983) Biochemical predisposition to dietary migraine: the role of phenolsulphotransferase.

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25.

None (1985) Migraine and muscle contraction headaches: a continuum.

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26.

Devoto M et al. (1986) Segregation analysis of migraine in 128 families.

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27.

Hiner BC et al. (1986) Antimigraine drug interactions with 5-hydroxytryptamine1A receptors.

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28.

Stewart WF et al. (1992) Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors.

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29.

None (1977) Migraine in twins.

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30.

OMIM.ORG article

Omim 157300 external link
31.

Wikipedia article

Wikipedia EN (Migraine) external link
Update: Aug. 14, 2020
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