The neuropathy of Morvan disease is characterized by progressive disturbances of sensory and autonomic nerves. The disease is inherited in an autosomal recessive pattern. Loss-of-function mutations of the WNK1 gene are responsible.
|Hereditary neurological disorders|
|Autosomal dominant cerebellar ataxia, deafness and narcolepsy|
|Autosomal recessive spastic paraplegia type 44|
|Brain malformations with urinary tract defects|
|Brain small vessel disease with hemorrhage|
|Congenital insensitivity to pain with anhidrosis|
|Hereditary benign chorea|
|Hereditary brain tumors|
|Hereditary distal motor neuron neuropathy type 5A|
|Hereditary muscle diseases|
|Hereditary sensory and autonomic neuropathy type 2A|
|Hereditary sensory neuropathy type 1E|
|Hypokalemic periodic paralysis 1|
|Hypomyelinating Leukodystrophy 2|
|Idiopathic basal ganglia calcification 1|
|Intellectual disability-severe speech delay-mild dysmorphism syndrome|
|Nemaline myopathy 5|
|Severe neonatal-onset encephalopathy with microcephaly|
|Spastic paraplegia 17 with amyotrophy of hands and feet|
|Susceptibility to glioma|
|Tuberous sclerosis complex|
|X-linked syndromic mental retardation 13|
None (1953) [A peculiar familial dystrophy; early inhibition of acral growth and non-mutilating acral osteolysis with facial dysmorphosis].
Sirinavin C et al. (1982) Digital clubbing, hyperhidrosis, acro-osteolysis and osteoporosis. A case resembling pachydermoperiostosis.
Ota M et al. (1973) Hereditary sensory neuropathy, type II. Clinical, electrophysiologic, histologic, and biochemical studies of a Quebec kinship.
Schoene WC et al. (1970) Hereditary sensory neuropathy. A clinical and ultrastructural study.
Hould F et al. (1967) [Hereditary radicular neuropathy with sensory loss: study of a French-Canadian family].
Freytag E et al. (1967) Neuropathologic findings in patients of a hospital for the mentally deficient. A survey of 359 cases.
Haddow JE et al. (1970) Congenital sensory neuropathy in siblings.
Barry JE et al. (1974) Congenital sensory neuropathy.
None (1973) Congenital sensory neuropathy.
Böckers M et al. (1989) Persistent skin ulcers, mutilations, and acro-osteolysis in hereditary sensory and autonomic neuropathy with phospholipid excretion. Report of a family.
None (1946) FAMILIAL PERIPHERAL NEUROPATHY.
Jedrzejowska H et al. (1976) Recessive hereditary sensory neuropathy.
Shekarabi M et al. (2008) Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.
Cho HJ et al. (2006) Novel mutation in the HSN2 gene in a Korean patient with hereditary sensory and autonomic neuropathy type 2.
Coen K et al. (2006) Novel mutations in the HSN2 gene causing hereditary sensory and autonomic neuropathy type II.
Roddier K et al. (2005) Two mutations in the HSN2 gene explain the high prevalence of HSAN2 in French Canadians.
Rivière JB et al. (2004) A mutation in the HSN2 gene causes sensory neuropathy type II in a Lebanese family.
Lafreniere RG et al. (2004) Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates.
OGDEN TE et al. (1959) Some sensory syndromes in children: indifference to pain and sensory neuropathy.
None () ////
None (1957) Familial ulcers, mutilating lesions of the extremities, and acro-osteolysis.
HELLER IH et al. (1955) Hereditary sensory neuropathy.
None (1952) Familial and sporadic neurogenic acro-osteolysis.
OMIM.ORG articleOmim 201300
Orphanet articleOrphanet ID 83467
Wikipedia articleWikipedia EN (Hereditary_sensory_and_autonomic_neuropathy)