Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Vascular dementia

Susceptibility to vascular dementia ay be caused by genetic factors.


Hereditary neurological disorders
Alzheimer disease
Arts syndrome
Ataxia-pancytopenia syndrome
Autosomal dominant cerebellar ataxia, deafness and narcolepsy
Autosomal recessive spastic paraplegia type 44
Brain malformations with urinary tract defects
Brain small vessel disease with hemorrhage
Brunner syndrome
Charcot-Marie-Tooth disease
Congenital insensitivity to pain with anhidrosis
Epilepsy syndrome
Hereditary benign chorea
Hereditary brain tumors
Hereditary distal motor neuron neuropathy type 5A
Hereditary muscle diseases
Hereditary sensory and autonomic neuropathy type 2A
Hereditary sensory neuropathy type 1E
Hypokalemic periodic paralysis 1
Hypomyelinating Leukodystrophy 2
Idiopathic basal ganglia calcification 1
Intellectual disability-severe speech delay-mild dysmorphism syndrome
Nemaline myopathy 5
Rett syndrome
Severe neonatal-onset encephalopathy with microcephaly
Spastic paraplegia 17 with amyotrophy of hands and feet
Susceptibility to glioma
Tuberous sclerosis complex
Vascular dementia
X-linked syndromic mental retardation 13



Szalai C et al. (2002) Association of polymorphisms and allelic combinations in the tumour necrosis factor-alpha-complement MHC region with coronary artery disease.

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Franchimont D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor.

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Fowler EV et al. (2005) TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease.

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Braumüller H et al. (2013) T-helper-1-cell cytokines drive cancer into senescence.

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de Groof F et al. (2002) Acute stress response in children with meningococcal sepsis: important differences in the growth hormone/insulin-like growth factor I axis between nonsurvivors and survivors.

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Buranawuti K et al. (2007) Variants in mannose-binding lectin and tumour necrosis factor alpha affect survival in cystic fibrosis.

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Witte JS et al. (2002) Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma.

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Shin HD et al. (2004) Association of tumor necrosis factor polymorphisms with asthma and serum total IgE.

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Aoki T et al. (2006) An association between asthma and TNF-308G/A polymorphism: meta-analysis.

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Lee YH et al. (2006) Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility.

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Wilson AG et al. (1992) Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product.

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Barnes PF et al. (1990) Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.

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None (1985) Tumor necrosis factor (TNF).

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Brenner DA et al. (1989) Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha.

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Carroll MC et al. (1987) Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

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Nedwin GE et al. (1985) Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.

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Aggarwal BB et al. () Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon.

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Müller U et al. () Tumour necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex.

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Ragoussis J et al. (1988) Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and III regions by field inversion gel electrophoresis.

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Spies T et al. (1986) Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

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Inoko H et al. (1987) Linkage of TNF genes to the HLA-B locus.

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Broudy VC et al. (1986) Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.

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Nedospasov SA et al. (1986) The genes for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse.

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Davis JM et al. (1987) Structure of human tumor necrosis factor alpha derived from recombinant DNA.

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Beutler B et al. (1986) Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance.

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Wang AM et al. (1985) Molecular cloning of the complementary DNA for human tumor necrosis factor.

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Shirai T et al. () Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.

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Pennica D et al. () Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

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Flynn JL et al. (1995) Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.

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Galbraith GM et al. (1995) Tumor necrosis factor alpha (TNF-alpha) gene polymorphism in alopecia areata.

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Cabrera M et al. (1995) Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.

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Norman RA et al. (1995) Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians.

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D'Alfonso S et al. (1994) A polymorphic variation in a putative regulation box of the TNFA promoter region.

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McGuire W et al. (1994) Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

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Cox A et al. (1994) Comparative analysis of the genetic associations of HLA-DR3 and tumour necrosis factor alpha with human IDDM.

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Van Ostade X et al. (1993) Human TNF mutants with selective activity on the p55 receptor.

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Spielman RS et al. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

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Obeid LM et al. (1993) Programmed cell death induced by ceramide.

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Bruce AJ et al. (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors.

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Mulcahy B et al. (1996) Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis.

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Nadel S et al. (1996) Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease.

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van Hensbroek MB et al. (1996) The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria.

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Black RA et al. (1997) A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.

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Conway DJ et al. (1997) Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid.

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Wilson AG et al. (1997) Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation.

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Moffatt MF et al. (1997) Tumour necrosis factor haplotypes and asthma.

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Marino MW et al. (1997) Characterization of tumor necrosis factor-deficient mice.

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Roy S et al. (1997) Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy.

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Uysal KT et al. (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.

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Herrmann SM et al. (1998) Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity.

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Ma JJ et al. (1998) Genetic contribution of the tumor necrosis factor region in Guillain-Barré syndrome.

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Zinman B et al. (1999) Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus.

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Bonifati C et al. (1999) Cytokines in psoriasis.

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Knight JC et al. (1999) A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.

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Skoog T et al. (1999) A common functional polymorphism (C-->A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha.

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Ruuls SR et al. (1999) Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models.

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None () The immunogenetics of resistance to malaria.

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Mira JP et al. (1999) Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study.

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Rasmussen SK et al. (2000) The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.

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Obayashi H et al. (2000) Tumor necrosis factor microsatellite polymorphism influences the development of insulin dependency in adult-onset diabetes patients with the DRB1*1502-DQB1*0601 allele and anti-glutamic acid decarboxylase antibodies.

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Winchester EC et al. (2000) Association of the TNF-alpha-308 (G-->A) polymorphism with self-reported history of childhood asthma.

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Ota N et al. (2000) Linkage of human tumor necrosis factor-alpha to human osteoporosis by sib pair analysis.

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Koss K et al. (2000) Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies.

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Moraes MO et al. (2001) Tumor necrosis factor-alpha promoter polymorphism TNF2 is associated with a stronger delayed-type hypersensitivity reaction in the skin of borderline tuberculoid leprosy patients.

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McCusker SM et al. (2001) Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study.

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Rosmond R et al. (2001) G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion.

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Escobar-Morreale HF et al. (2001) TNF-alpha and hyperandrogenism: a clinical, biochemical, and molecular genetic study.

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Quasney MW et al. (2001) Increased frequency of the tumor necrosis factor-alpha-308 A allele in adults with human immunodeficiency virus dementia.

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Keane J et al. (2001) Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.

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Beattie EC et al. (2002) Control of synaptic strength by glial TNFalpha.

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Roach DR et al. (2002) TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection.

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Gorman JD et al. (2002) Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha.

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van Heel DA et al. (2002) Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.

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Janssen R et al. (2002) Divergent role for TNF-alpha in IFN-gamma-induced killing of Toxoplasma gondii and Salmonella typhimurium contributes to selective susceptibility of patients with partial IFN-gamma receptor 1 deficiency.

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Krikovszky D et al. (2002) Association between G-308A polymorphism of the tumor necrosis factor-alpha gene and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents.

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García-Ruiz C et al. (2003) Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice.

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Flori L et al. (2003) Linkage of mild malaria to the major histocompatibility complex in families living in Burkina Faso.

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Takahashi JL et al. (2003) Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity.

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Balding J et al. (2003) Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity.

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Shbaklo H et al. (2003) No association between the -1031 polymorphism in the TNF-alpha promoter region and type 1 diabetes.

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Li H et al. (2003) A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor alpha promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes.

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Kim YJ et al. (2003) Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection.

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Steed PM et al. (2003) Inactivation of TNF signaling by rationally designed dominant-negative TNF variants.

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Leonardi CL et al. (2003) Etanercept as monotherapy in patients with psoriasis.

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Diwan A et al. (2004) Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.

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Rainero I et al. (2004) Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine.

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Bouwmeester T et al. (2004) A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

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Boyman O et al. (2004) Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha.

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Allcock RJ et al. (2004) High-Density SNP genotyping defines 17 distinct haplotypes of the TNF block in the Caucasian population: implications for haplotype tagging.

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Funayama T et al. (2004) Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.

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Kamata H et al. (2005) Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases.

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Vielhauer V et al. (2005) Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis.

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Balosso S et al. (2005) Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors.

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Kim JY et al. (2005) Identification of regulatory polymorphisms in the TNF-TNF receptor superfamily.

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Laws SM et al. (2005) TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.

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Stein CM et al. (2005) Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis.

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Murray RZ et al. (2005) A role for the phagosome in cytokine secretion.

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Stellwagen D et al. (2006) Synaptic scaling mediated by glial TNF-alpha.

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El-Shabrawi Y et al. (2006) Polymorphisms within the tumor necrosis factor-alpha promoter region in patients with HLA-B27-associated uveitis: association with susceptibility and clinical manifestations.

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Ramos EM et al. (2006) Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease.

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Hase H et al. (2006) TNFalpha mediates the skeletal effects of thyroid-stimulating hormone.

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Kawane K et al. (2006) Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.

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Nadkarni S et al. (2007) Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta.

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Soller JT et al. (2007) Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians.

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Lieu ZZ et al. (2008) A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo.

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Li X et al. (2008) A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease.

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Guo R et al. (2008) Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.

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Tay S et al. (2010) Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing.

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Feldmann M et al. (2010) Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

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Huang MT et al. (2010) Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis.

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Günther C et al. (2011) Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

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Li Z et al. (2014) The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL.

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OMIM.ORG article

Omim 191160 external link

Wikipedia article

Wikipedia EN (Vascular_dementia) external link
Update: Aug. 14, 2020
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