Der Hageman-Faktor-Mangel ist ein Mangel an Gerinnungsfaktor 12 der durch Mutationen im F12-Gen ausgelöst wird. Die Erkrankung äußert sich auch im homozygoten Zustand nur in einer milden Gerinnungsstörung oder Thrombophilie. Erstaunlicherweise finden sich auch bei einigen heterozygoten Anlageträgern mit noch vorhandener Restaktivität Abnormalitäten des Gerinnungssystems.
Erbliche Blutungsübel | ||||
Afibrinogenämie | ||||
Dysfibrinogenemie | ||||
Faktor XII-Mangel | ||||
F12 | ||||
Faktor XIII A-Mangel | ||||
Faktor XIII B-Mangel | ||||
Plasminogen-Aktivator-Inhibitor-Mangel | ||||
Störungen des Vitamin K-Stoffwechsels | ||||
1. |
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2. |
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3. |
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4. |
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5. |
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6. |
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7. |
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8. |
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9. |
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10. |
None (1980) A quarter century with Mr. Hageman. |
12. |
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13. |
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14. |
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15. |
Samlaska CP et al. (1990) Superficial migratory thrombophlebitis and factor XII deficiency. |
16. |
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17. |
Donaldson VH et al. (1977) Fatal vascular disease in a patient with Hageman trait and a connective-tissue disorder. |
18. |
Lucia JF et al. (1979) Factor-XII congenital deficiency. A new family study. |
19. |
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20. |
None (1964) AN ENZYME CASCADE IN THE BLOOD CLOTTING MECHANISM, AND ITS FUNCTION AS A BIOCHEMICAL AMPLIFIER. |
21. |
None (2003) Oscar Ratnoff: his contributions to the golden era of coagulation research. |
22. |
Josso F et al. (1968) [Probable localisation of a Hageman (factor XII) locus on an autosome]. |
23. |
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24. |
OMIM.ORG article Omim 234000 |