Laminin subunit alpha-5
The LAMA5 gene encodes a subunit of laminin an component ob basement mebranes. Mutations are described in connection with FSGS.
Genetests:
Related Diseases:
References:
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Ma GC et al. (2008) A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy.
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Secolin R et al. (2013) Refinement of chromosome 3p22.3 region and identification of a susceptibility gene for bipolar affective disorder.
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Miner JH et al. (1995) Molecular cloning of a novel laminin chain, alpha 5, and widespread expression in adult mouse tissues.
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Durkin ME et al. (1997) Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.
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Nagase T et al. (1998) Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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Nagase T et al. (2001) Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.
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Li J et al. (2003) Laminin-10 is crucial for hair morphogenesis.
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Gao J et al. (2008) Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.
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Wu C et al. (2009) Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.
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Orphanet article
Orphanet ID 470582
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NCBI article
NCBI 3911
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OMIM.ORG article
Omim 601033
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13. |
Wikipedia article
Wikipedia EN (Laminin,_alpha_5)
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Update: Aug. 14, 2020