Hereditary FSGS type 2

Hereditary FSGS type 2 is an autosomal dominant disorder caused by mutations of the TRPC6 gene. To the moment it is not clear yet whether exclusively gain-of-function mutations can cause that disorder or loss-of-funtion mutations also.

Systematic

Focal, segmental glomerulosclerosis (FSGS)
	ALG13
	ARHGAP24
	CLU
	Hereditary FSGS type 1
	Hereditary FSGS type 2
		TRPC6
	Hereditary FSGS type 3
	Hereditary FSGS type 4
	Hereditary FSGS type 5
	Hereditary FSGS type 6
	Hereditary FSGS type 7
	Hereditary FSGS type 8
	Hereditary FSGS type 9
	ITGA9
	LAMA5
	NXF5

References:

1.	Büscher AK et al. (2012) Mutations in podocyte genes are a rare cause of primary FSGS associated with ESRD in adult patients.

2.	Riehle M et al. (2016) TRPC6 G757D Loss-of-Function Mutation Associates with FSGS.

3.	OMIM.ORG article Omim 603965