Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The CAPN10 gene encodes calcium-dependent cysteine proteases. Mutations of the gene are associated with non-insulin-dependent diabetes mellitus 1 (NIDDM1).
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Hanis CL et al. (1996) A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. 
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| 2. |
Carlsson E et al. (2004) Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects.
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| 3. |
Song Y et al. (2004) Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies.
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| 4. |
Gonzalez A et al. (2003) Specific CAPN10 gene haplotypes influence the clinical profile of polycystic ovary patients.
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| 5. |
Weedon MN et al. (2003) Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
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| 6. |
Horikawa Y et al. (2003) Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese.
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| 7. |
Gonzalez A et al. (2002) Comment: CAPN10 alleles are associated with polycystic ovary syndrome.
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| 8. |
Hoffstedt J et al. (2002) Calpain-10 gene polymorphism is associated with reduced beta(3)-adrenoceptor function in human fat cells.
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| 9. |
Ehrmann DA et al. (2002) Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome.
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| 10. |
Fullerton SM et al. (2002) Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus.
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| 11. |
Elbein SC et al. (2002) Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians.
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| 12. |
Tsai HJ et al. (2001) Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association.
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| 13. |
Evans JC et al. (2001) Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom.
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| 14. |
Weiss KM et al. (2000) How many diseases does it take to map a gene with SNPs?
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| 15. |
Kang ES et al. (2006) A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes.
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| 16. |
None (2001) Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene.
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| 17. |
Altshuler D et al. (2000) Guilt by association.
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| 18. |
Horikawa Y et al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
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| 19. |
NCBI article NCBI 11132
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| 20. |
OMIM.ORG article Omim 605286
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| 21. |
Wikipedia article Wikipedia EN (CAPN10)
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