IL17RA-Gen
Das IL17RA-Gen kodiert ein transmemranöses Protein, den Interleukin 17A-Rezeptor. Das Interleukin 17A spielt eine wichtige Rolle bei verschiedenen inflammatorischen und Autoimmunerkrankungen, wie Rheumatoid Arthritis. Mutationen sind für den autosomal rezessiven Immundefekt 51 verantwortlich.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Yao Z et al. (1995) Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
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2. |
Yao Z et al. (1997) Molecular characterization of the human interleukin (IL)-17 receptor.
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3. |
Footz TK et al. (2001) Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.
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4. |
McAllister F et al. (2005) Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis.
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5. |
Tan W et al. (2006) IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation.
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6. |
Toy D et al. (2006) Cutting edge: interleukin 17 signals through a heteromeric receptor complex.
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7. |
Maitra A et al. (2007) Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression.
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8. |
Priebe GP et al. (2008) IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa.
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9. |
Kudva A et al. (2011) Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice.
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10. |
Puel A et al. (2011) Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity.
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11. |
Freches D et al. (2013) Mice genetically inactivated in interleukin-17A receptor are defective in long-term control of Mycobacterium tuberculosis infection.
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12. |
Lévy R et al. (2016) Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency.
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Update: 14. August 2020