Siponimod ist ein Arneimittel zur Behandlung von erwachsenen Patienten mit sekundär progredienter Multipler Sklerose. Laut Fachinformation sollte zusätzlich eine Krankheitsaktivität entweder durch die Beobachtung von Schüben oder mittels Bildgebung nachgewiesen sein. Die Dosierung ist streng von den vorhandenen CYP2C9-Varianten abhängig die vorher bestimmt werden müssen.
Störungen im Cytochrom P450-System | ||||
CYP1A2 | ||||
CYP2A6 | ||||
CYP2C9 | ||||
CYP2D6 | ||||
CYP3A4 | ||||
CYP4F2 | ||||
Siponimod-Intoleranz | ||||
CYP2C9 | ||||
1. |
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Novartis: Mayzent® (Siponimod) Informationen zur sicheren Anwendung |
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