Tyrosine-protein kinase ITK/TSK

Hwang ES et al. (2005) T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

Janis EM et al. (1994) Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.

Cheng G et al. (1994) Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

Gibson S et al. (1993) Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.

Schaeffer EM et al. (1999) Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.

Woods ML et al. (2001) A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor.

Atherly LO et al. (2006) The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.

Broussard C et al. (2006) Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

Dubois S et al. (2006) ITK and IL-15 support two distinct subsets of CD8+ T cells.

Huang YH et al. (2007) Positive regulation of Itk PH domain function by soluble IP4.

Huck K et al. (2009) Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.

Stepensky P et al. (2011) IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach.

Linka RM et al. (2012) Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases.