Small ubiquitin-related modifier 4
The SUMO4 gene encodes a regulator of ubiquitination, in particular of proteins associated with NF-kappa-B signaling. It plays therefore a significant role in inflammation and immune regulation. Genetic variants are associated with susceptibility to type 1 diabetes.
Genetests:
Related Diseases:
References:
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Bohren KM et al. (2004) A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.
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Guo D et al. (2004) A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.
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Smyth DJ et al. (2005) Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
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Qu H et al. (2005) Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
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Park Y et al. (2005) Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
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Update: Aug. 14, 2020