Macrophage migration inhibitory factor
The MIF gene encodes a cytokine which is involved in immune regulation and inflammation. Genetic variants influences the susceptibility to juvenile arthritis.
Genetests:
Related Diseases:
References:
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Pastrana DV et al. (1998) Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.
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Miller EJ et al. (2008) Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.
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Arjona A et al. (2007) Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion.
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Bernhagen J et al. (2007) MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.
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Wang B et al. (2006) Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.
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Amin MA et al. (2003) Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase.
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De Benedetti F et. al. (2003) Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis.
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Donn R et. al. (2002) Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis.
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Koebernick H et al. (2002) Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium.
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Roger T et al. () MIF regulates innate immune responses through modulation of Toll-like receptor 4.
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Donn RP et. al. (2001) A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis.
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Kleemann R et al. (2000) Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.
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Weiser WY et al. (1989) Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor.
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Esumi N et al. (1998) Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF.
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15. |
Rossi AG et al. (1998) Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.
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Budarf M et al. (1997) Localization of the human gene for macrophage migration inhibitory factor (MIF) to chromosome 22q11.2.
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None (1996) MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response.
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Bernhagen J et al. (1993) MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia.
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Paralkar V et al. (1994) Cloning the human gene for macrophage migration inhibitory factor (MIF).
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Bozza M et al. (1995) Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.
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Kozak CA et al. (1995) Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.
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22. |
Bloom BR et al. (1966) Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.
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23. |
None (1966) Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.
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Update: Aug. 14, 2020