Interleukin-10 receptor subunit beta
The IL10RB gene encodes a component of the interleukin 10 receptor which is involved in IL10 signal transduction. Mutations cause autosomal recessive IL10R-Deficiency wich presents as inflammatory bowel disease 25. Also, a genetic variant predisposes to heptitis B virus persistence.
Genetests:
Related Diseases:
References:
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Lutfalla G et. al. (1993) A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.
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Cheng S et. al. (1993) GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16.
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Gibbs VC et. al. (1997) CRF2-4: isolation of cDNA clones encoding the human and mouse proteins.
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Kotenko SV et. al. (1997) Identification and functional characterization of a second chain of the interleukin-10 receptor complex.
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Spencer SD et. al. (1998) The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor.
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Sheppard P et. al. (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R.
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Sheikh F et. al. (2004) Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.
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Frodsham AJ et. al. (2006) Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
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Glocker EO et. al. (2009) Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
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Begue B et. al. (2011) Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease.
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Update: Aug. 14, 2020