Canalicular multispecific organic anion transporter 1
The ABCC2 gene encodes an ATP dependent membrane transport protein. Mutations are associated with statin intolerance.
Genetests:
Related Diseases:
References:
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None (1993) Dubin-Johnson and Rotor syndromes: molecular basis and pathogenesis.
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Xu K et al. (2012) miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2.
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Materna V et al. (2003) Homozygous mutation Arg768Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a Caucasian patient.
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4. |
Evers R et al. (1998) Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.
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Gopalan G et al. (1998) Chromosome localization of two new mammalian kinases related to yeast and fly chromosome segregation-regulators.
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Taniguchi K et al. (1996) A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.
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7. |
Pacifico L et al. (2010) Mutational analysis of ABCC2 gene in two siblings with neonatal-onset Dubin Johnson syndrome.
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8. |
Mor-Cohen R et al. (2001) Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome.
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Toh S et al. (1999) Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome.
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10. |
Kajihara S et al. (1998) A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome.
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11. |
Wada M et al. (1998) Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome.
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12. |
van Kuijck MA et al. (1997) Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization.
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13. |
Ito K et al. (1997) Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.
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14. |
Paulusma CC et al. (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.
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15. |
Shani M et al. (1970) Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases.
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NCBI article
NCBI 1244
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OMIM.ORG article
Omim 601107
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Orphanet article
Orphanet ID 117652
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Wikipedia article
Wikipedia EN (Multidrug_resistance-associated_protein_2)
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Update: Aug. 14, 2020