Tribbles homolog 1
The TRIB1 gene encodes a regulator of the carbohydrate metabolism with implications on lipid metabolism. Therefore in genome-wide association studies this locus is found connected with lipid disorders and coronary artery disease. The exact mechanism by which this protein exerts its effect is yet unknown.
Genetests:
Related Diseases:
References:
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Wilkin F et al. (1997) Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.
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Eyers PA et al. (2017) Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.
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3. |
Stein SJ et al. (2015) Tribbles in normal and malignant haematopoiesis.
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4. |
Kahali B et al. (2015) Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.
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5. |
Iwamoto S et al. (2015) The role of TRIB1 in lipid metabolism; from genetics to pathways.
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6. |
Bauer RC et al. (2015) Tribbles-1: a novel regulator of hepatic lipid metabolism in humans.
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7. |
Ahmadzadeh A et al. (2014) Genes associated with low serum high-density lipoprotein cholesterol.
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8. |
Bauer RC et al. (2011) Functional validation of new pathways in lipoprotein metabolism identified by human genetics.
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9. |
Hegedus Z et al. (2006) Tribbles: novel regulators of cell function; evolutionary aspects.
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10. |
Yoshida A et al. (2013) COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.
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Satoh T et al. (2013) Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.
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12. |
Kiss-Toth E et al. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
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13. |
Storlazzi CT et al. (2004) Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies.
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14. |
Wu M et al. (2003) SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.
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15. |
Cefalù AB et al. () Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing.
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16. |
NCBI article
NCBI 10221
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17. |
OMIM.ORG article
Omim 609461
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18. |
Wikipedia article
Wikipedia EN (TRIB1)
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Update: Aug. 14, 2020