TBC1 domain family member 1
The TBC1D1 encodes a protein that is involved in cell growth and differentiation. In particular this holds true in processes and cells of glucose regulation.
Genetests:
Related Diseases:
References:
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Kikuno R et al. (1999) Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
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White RA et al. (2000) The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4.
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Chadt A et al. (2008) Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.
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Paglialunga S et al. (2017) The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.
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Jaldin-Fincati JR et al. (2017) Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action.
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Zhou Z et al. (2017) Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.
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Møller CL et al. (2016) α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK.
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Dokas J et al. (2016) Tbc1d1 deletion suppresses obesity in leptin-deficient mice.
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NCBI article
NCBI 23216
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OMIM.ORG article
Omim 609850
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11. |
Wikipedia article
Wikipedia EN (TBC1D1)
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Update: Aug. 14, 2020