Fibroblast growth factor 8
The FGF8 gene encodes an androgen-induced growth factor. Mutations cause autosomal recessive or dominant hypogonadotropic hypogonadism 6 with or without anosmia.
Genetests:
Related Diseases:
References:
1. |
Olsen SK et al. (2006) Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.
|
2. |
Trainor PA et al. (2002) Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning.
|
3. |
Zammit C et al. (2002) Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer.
|
4. |
Sun X et al. (2002) Functions of FGF signalling from the apical ectodermal ridge in limb development.
|
5. |
Dudley AT et al. (2002) A re-examination of proximodistal patterning during vertebrate limb development.
|
6. |
Storm EE et al. (2003) Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain.
|
7. |
Gunhaga L et al. (2003) Specification of dorsal telencephalic character by sequential Wnt and FGF signaling.
|
8. |
Fukuchi-Shimogori T et al. (2003) Emx2 patterns the neocortex by regulating FGF positional signaling.
|
9. |
Dubrulle J et al. (2004) fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo.
|
10. |
Ladher RK et al. (2005) FGF8 initiates inner ear induction in chick and mouse.
|
11. |
Martinez-Morales JR et al. (2005) Differentiation of the vertebrate retina is coordinated by an FGF signaling center.
|
12. |
Tanaka Y et al. (2005) FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.
|
13. |
Thomas BL et al. (2000) Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch.
|
14. |
Mariani FV et al. (2008) Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning.
|
15. |
Verheyden JM et al. (2008) An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.
|
16. |
Yu SR et al. (2009) Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules.
|
17. |
Watanabe Y et al. (2010) Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.
|
18. |
Arauz RF et al. (2010) A Hypomorphic Allele in the FGF8 Gene Contributes to Holoprosencephaly and Is Allelic to Gonadotropin-Releasing Hormone Deficiency in Humans.
|
19. |
Nowak M et al. (2011) Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking.
|
20. |
Naiche LA et al. (2011) FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis.
|
21. |
Cooper KL et al. (2011) Initiation of proximal-distal patterning in the vertebrate limb by signals and growth.
|
22. |
Roselló-Díez A et al. (2011) Diffusible signals, not autonomous mechanisms, determine the main proximodistal limb subdivision.
|
23. |
Boulet AM et al. (2012) Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo.
|
24. |
Nacu E et al. (2016) FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration.
|
25. |
Dubrulle J et al. (2001) FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation.
|
26. |
Johnson RL et al. (1997) Molecular models for vertebrate limb development.
|
27. |
Copeland NG et al. (1993) A genetic linkage map of the mouse: current applications and future prospects.
|
28. |
Riley BM et al. (2007) Impaired FGF signaling contributes to cleft lip and palate.
|
29. |
Jung J et al. (1999) Initiation of mammalian liver development from endoderm by fibroblast growth factors.
|
30. |
Falardeau J et al. (2008) Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice.
|
31. |
Neugebauer JM et al. (2009) FGF signalling during embryo development regulates cilia length in diverse epithelia.
|
32. |
Tanaka A et al. (1995) Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties.
|
33. |
Mattei MG et al. (1995) Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively.
|
34. |
Lorenzi MV et al. (1995) Expression cloning, developmental expression and chromosomal localization of fibroblast growth factor-8.
|
35. |
White RA et al. (1995) Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region.
|
36. |
Gemel J et al. (1996) Structure and sequence of human FGF8.
|
37. |
Payson RA et al. (1996) The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells.
|
38. |
Ghosh AK et al. (1996) Molecular cloning and characterization of human FGF8 alternative messenger RNA forms.
|
39. |
Yoshiura K et al. (1997) Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes.
|
40. |
Meyers EN et al. (1998) An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination.
|
41. |
Meyers EN et al. (1999) Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.
|
42. |
Sun X et al. (1999) Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.
|
43. |
Sun X et al. (2000) Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development.
|
44. |
Streit A et al. (2000) Initiation of neural induction by FGF signalling before gastrulation.
|
45. |
Moon AM et al. (2000) Fgf8 is required for outgrowth and patterning of the limbs.
|
46. |
Lewandoski M et al. (2000) Fgf8 signalling from the AER is essential for normal limb development.
|
47. |
Fukuchi-Shimogori T et al. (2001) Neocortex patterning by the secreted signaling molecule FGF8.
|
48. |
Orphanet article
Orphanet ID 173149
|
49. |
NCBI article
NCBI 2253
|
50. |
OMIM.ORG article
Omim 600483
|
51. |
Wikipedia article
Wikipedia EN (FGF8)
|
Update: Aug. 14, 2020