Bone morphogenetic protein 4
The BMP4 gene encodes a hormone which binds to the TGF-beta receptor. The hormone is involveld in regulation of heart development and adipogenesis. Mutations cause autosomal dominant syndromic microphthalmia 6 which also involves urogenital malformations, and if restricted to facial dysmorphisms only, orofacial cleft 11 may be observed.
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References:
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Zhu NL et al. (2004) NKX2.1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells.
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Shore EM et al. (1998) The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation.
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Tucker AS et al. (1998) Transformation of tooth type induced by inhibition of BMP signaling.
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Thomas BL et al. (2000) Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch.
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Dooley CA et al. (2000) Bone morphogenetic protein inhibits ovarian androgen production.
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Monsoro-Burq A et al. (2001) BMP4 plays a key role in left-right patterning in chick embryos by maintaining Sonic Hedgehog asymmetry.
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Chen Y et al. (2002) In vivo new bone formation by direct transfer of adenoviral-mediated bone morphogenetic protein-4 gene.
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Paez-Pereda M et al. (2003) Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk.
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Jiao K et al. (2003) An essential role of Bmp4 in the atrioventricular septation of the mouse heart.
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Cheng H et al. (2003) Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).
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Haramis AP et al. (2004) De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.
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Tang QQ et al. (2004) Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage.
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Bowers RR et al. (2006) Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene.
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14. |
Fuller ML et al. (2007) Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions.
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Wang X et al. (2008) Type IV collagens regulate BMP signalling in Drosophila.
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Bénazet JD et al. (2009) A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning.
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Goldman DC et al. (2009) BMP4 regulates the hematopoietic stem cell niche.
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van den Wijngaard A et al. (1996) Genomic organization of the human bone morphogenetic protein-4 gene: molecular basis for multiple transcripts.
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Wandzioch E et al. (2009) Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.
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Cejalvo T et al. (2007) Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development.
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21. |
Plikus MV et al. (2008) Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration.
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Dickinson ME et al. (1990) Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.
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Kan L et al. (2004) Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype.
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Shafritz AB et al. (1996) Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva.
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Wordinger RJ et al. (2007) Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma.
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Piccirillo SG et al. (2006) Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.
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Bakrania P et al. (2008) Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways.
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Reis LM et al. (2011) BMP4 loss-of-function mutations in developmental eye disorders including SHORT syndrome.
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Liu W et al. (2005) Distinct functions for Bmp signaling in lip and palate fusion in mice.
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Suzuki S et al. (2009) Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip.
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Furuta Y et al. (1998) BMP4 is essential for lens induction in the mouse embryo.
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van den Wijngaard A et al. (1995) Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization.
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33. |
Tabas JA et al. (1993) Chromosomal assignment of the human gene for bone morphogenetic protein 4.
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None (1996) Fibrodysplasia ossificans progressiva -- lessons from rare maladies.
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Orphanet article
Orphanet ID 140047
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NCBI article
NCBI 652
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OMIM.ORG article
Omim 112262
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Wikipedia article
Wikipedia EN (Bone_morphogenetic_protein_4)
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Update: Aug. 14, 2020