Upstream stimulatory factor 1
This gene encodes a transcription factor which is involved in regulation of adipose tissue metabolism. Variations have been reported to be associated with familial combined hyperlipidemia.
Genetests:
Research |
Method |
Carrier testing |
Turnaround |
5 days |
Specimen type |
genomic DNA |
Related Diseases:
References:
1. |
Putt W et al. (2004) Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II.
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2. |
van der Vleuten GM et al. (2007) The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia.
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3. |
Lee JC et al. (2007) USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.
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4. |
Huertas-Vazquez A et al. (2005) Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1.
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5. |
Wu S et al. (2010) Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice.
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6. |
Naukkarinen J et al. (2005) USF1 and dyslipidemias: converging evidence for a functional intronic variant.
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7. |
None (2004) USF1 on trial.
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8. |
Yago M et al. (2002) Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase.
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9. |
Zhong G et al. (2001) Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors.
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10. |
Casado M et al. (1999) Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver.
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11. |
Vallet VS et al. (1998) Differential roles of upstream stimulatory factors 1 and 2 in the transcriptional response of liver genes to glucose.
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12. |
None (1998) Identification of upstream stimulatory factor as transcriptional activator of the liver promoter of the glucokinase gene.
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13. |
Roy AL et al. (1997) Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1.
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14. |
Viollet B et al. (1996) Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.
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15. |
Steingrímsson E et al. (1995) Murine chromosomal location of five bHLH-Zip transcription factor genes.
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16. |
Shieh BH et al. (1993) Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23.
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17. |
Sirito M et al. (1994) Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells.
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18. |
Lefrançois-Martinez AM et al. (1995) Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.
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19. |
Henrion AA et al. (1995) Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse.
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20. |
Gregor PD et al. (1990) The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.
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21. |
Coon H et al. (2005) Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides.
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22. |
Pajukanta P et al. (2004) Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).
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23. |
NCBI article
NCBI 7391
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24. |
OMIM.ORG article
Omim 191523
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25. |
Wikipedia article
Wikipedia EN (USF1)
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Update: Aug. 14, 2020