Growth hormone secretagogue receptor
The GHSR gene encodes a G-protein coupled receptor which regulates growth hormone secretion in response to several secretagogues, most important is ghrelin a gastric hormone, which regulates growth depending on food intake. Mutations cause GSH resistance, a genetic disorder that shows variable types of inheritance and variable penetrance.
Genetests:
Related Diseases:
References:
1. |
Kaji H et al. (2001) Hormonal regulation of the human ghrelin receptor gene transcription.
|
2. |
García A et al. (2001) Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor.
|
3. |
Dixit VD et al. (2004) Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells.
|
4. |
Zigman JM et al. (2005) Mice lacking ghrelin receptors resist the development of diet-induced obesity.
|
5. |
Pantel J et al. (2006) Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.
|
6. |
Pantel J et al. (2009) Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor.
|
7. |
Howard AD et al. (1996) A receptor in pituitary and hypothalamus that functions in growth hormone release.
|
8. |
McKee KK et al. (1997) Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.
|
9. |
Orphanet article
Orphanet ID 201252
|
10. |
NCBI article
NCBI 2693
|
11. |
OMIM.ORG article
Omim 601898
|
12. |
Wikipedia article
Wikipedia EN (Growth_hormone_secretagogue_receptor)
|
Update: Aug. 14, 2020