Insulin-like growth factor 1 (somatomedin C)
The IGF1 gene encodes a cytikin that mediates the effect of growth hormone in several tissues. Mutations cause autosomal recessive igf1 deficiency.
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References:
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Takano K et al. (2010) Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation.
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Morton CC et al. (1986) Human genes for insulin-like growth factors I and II and epidermal growth factor are located on 12q22--q24.1, 11p15, and 4q25--q27, respectively.
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Mathews LS et al. (1986) Regulation of insulin-like growth factor I gene expression by growth hormone.
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None (1986) Two insulin-like growth factor I messenger RNAs are expressed in human liver.
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Höppener JW et al. (1985) The human gene encoding insulin-like growth factor I is located on chromosome 12.
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Rotwein P et al. (1986) Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.
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Le Bouc Y et al. (1986) Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library.
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Guler HP et al. (1989) Small stature and insulin-like growth factors: prolonged treatment of mini-poodles with recombinant human insulin-like growth factor I.
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Rapp R et al. (1988) Characterization of the protein which binds insulin-like growth factor in human serum.
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Bowcock A et al. (1990) Polymorphism and mapping of the IGF1 gene, and absence of association with stature among African Pygmies.
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11. |
Daughaday WH et al. (1972) Somatomedin: proposed designation for sulphation factor.
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Mayack SR et al. (2010) Systemic signals regulate ageing and rejuvenation of blood stem cell niches.
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Pouladi MA et al. (2010) Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.
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14. |
Taylor BA et al. (1991) Localization of the gene encoding insulin-like growth factor I on mouse chromosome 10.
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15. |
Justice MJ et al. (1990) A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.
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Schoenle EJ et al. (1991) Recombinant human insulin-like growth factor I (rhIGF I) reduces hyperglycaemia in patients with extreme insulin resistance.
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Mullis PE et al. (1991) Growth characteristics and response to growth hormone therapy in patients with hypochondroplasia: genetic linkage of the insulin-like growth factor I gene at chromosome 12q23 to the disease in a subgroup of these patients.
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18. |
Kim SW et al. (1991) Structure and function of a human insulin-like growth factor-I gene promoter.
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19. |
Johansson M et al. (2007) Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels.
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20. |
Van Wyk JJ et al. (1980) Evidence from radioligand assays that somatomedin-C and insulin-like growth factor-I are similar to each other and different from other somatomedins.
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21. |
Hankinson SE et al. (1998) Circulating concentrations of insulin-like growth factor-I and risk of breast cancer.
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22. |
None (1998) Insulin-like growth factor-I and new opportunities for cancer prevention.
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23. |
Bianda T et al. (1998) Effects of short-term insulin-like growth factor-I (IGF-I) or growth hormone (GH) treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults.
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Zhu J et al. (1997) Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system.
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Lembo G et al. (1996) Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.
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Woods KA et al. (1996) Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.
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Baker J et al. (1993) Role of insulin-like growth factors in embryonic and postnatal growth.
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Powell-Braxton L et al. (1993) IGF-I is required for normal embryonic growth in mice.
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Geary MP et al. (2003) Sexual dimorphism in the growth hormone and insulin-like growth factor axis at birth.
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Copeland KC et al. (1980) Induction of immunoreactive somatomedin C human serum by growth hormone: dose-response relationships and effect on chromatographic profiles.
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Svoboda ME et al. (1980) Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins.
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32. |
Li CH et al. (1983) Total synthesis of insulin-like growth factor I (somatomedin C).
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33. |
Tricoli JV et al. () Localization of insulin-like growth factor genes to human chromosomes 11 and 12.
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34. |
Brissenden JE et al. () Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor.
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35. |
Jansen M et al. () Sequence of cDNA encoding human insulin-like growth factor I precursor.
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36. |
Rinderknecht E et al. (1978) The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.
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Ullrich A et al. (1984) Isolation of the human insulin-like growth factor I gene using a single synthetic DNA probe.
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Yakar S et al. (1999) Normal growth and development in the absence of hepatic insulin-like growth factor I.
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Musarò A et al. (2001) Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle.
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Le Roith D et al. (2001) What is the role of circulating IGF-I?
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Yanovski JA et al. (2000) Insulin-like growth factors and bone mineral density in African American and White girls.
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Harman SM et al. (2000) Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer.
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Playford MP et al. (2000) Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.
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Musarò A et al. (1999) IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.
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Semsarian C et al. (1999) Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway.
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Vestergaard P et al. (1999) Effect of sex hormone replacement on the insulin-like growth factor system and bone mineral: a cross-sectional and longitudinal study in 595 perimenopausal women participating in the Danish Osteoporosis Prevention Study.
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47. |
Kim S et al. (2007) Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform.
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48. |
Sjögren K et al. (1999) Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice.
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49. |
Aleman A et al. (1999) Insulin-like growth factor-I and cognitive function in healthy older men.
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Goddard AD et al. (1995) Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group.
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Liu JP et al. (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).
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Ueki K et al. (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
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Lambooij AC et al. (2003) Insulin-like growth factor-I and its receptor in neovascular age-related macular degeneration.
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Rasmussen SK et al. (2000) Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus.
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55. |
Lin SC et al. (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth.
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Smith PJ et al. (2002) An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor.
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None (2007) Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway.
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Sutter NB et al. (2007) A single IGF1 allele is a major determinant of small size in dogs.
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Kurosu H et al. (2005) Suppression of aging in mice by the hormone Klotho.
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Walenkamp MJ et al. (2005) Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation.
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Ruberte J et al. (2004) Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.
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Usala AL et al. (1992) Brief report: treatment of insulin-resistant diabetic ketoacidosis with insulin-like growth factor I in an adolescent with insulin-dependent diabetes.
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Sussenbach JS et al. (1992) Structure and expression of the human insulin-like growth factor genes.
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Bonapace G et al. (2003) A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency.
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None (2003) Insulin-like growth factors and the basis of growth.
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Johnston LB et al. (2003) Association between insulin-like growth factor I (IGF-I) polymorphisms, circulating IGF-I, and pre- and postnatal growth in two European small for gestational age populations.
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Carro E et al. (2002) Serum insulin-like growth factor I regulates brain amyloid-beta levels.
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Simó R et al. (2002) Free insulin growth factor-I and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy.
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Humbert S et al. (2002) The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
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Arends N et al. (2002) Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA).
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Vaessen N et al. (2002) Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight.
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Barton ER et al. (2002) Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice.
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Hellstrom A et al. (2001) Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity.
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NCBI article
NCBI 3479
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OMIM.ORG article
Omim 147440
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Orphanet article
Orphanet ID 122587
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Wikipedia article
Wikipedia EN (Insulin-like_growth_factor_1)
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Update: Aug. 14, 2020