Transient receptor potential cation channel, subfamily M, member 7
This TRPM7 gene resembles TRPM6 in its ability to channel divalent cations including magnesium, so it might play a role magnesium homeostasis. Genetic variations are associated with amyotrophic lateral sclerosis, too.
Genetests:
Related Diseases:
References:
1. |
Schmitz C et al. (2005) The channel kinases TRPM6 and TRPM7 are functionally nonredundant.
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2. |
Li M et al. (2006) Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.
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3. |
Schlingmann KP et al. (2007) TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism.
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4. |
Li M et al. (2007) Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7.
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5. |
OMIM.ORG article
Omim 605692
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6. |
Orphanet article
Orphanet ID 159298
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7. |
NCBI article
NCBI 54822
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8. |
Wikipedia article
Wikipedia EN (TRPM7)
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Update: Aug. 14, 2020