Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Psoriasis susceptibility 7

Psoriasis is quite heritable. It is associated with various loci throughout the genome. The type 7 susceptibility is associates with 1p.

Systematic

Psoriasis
CARD14 associated psoriasis
Psoriasis 14
Psoriasis 15
Psoriasis susceptibility 1
Psoriasis susceptibility 10
Psoriasis susceptibility 11
Psoriasis susceptibility 12
Psoriasis susceptibility 13
Psoriasis susceptibility 3
Psoriasis susceptibility 4
Psoriasis susceptibility 5
Psoriasis susceptibility 6
Psoriasis susceptibility 7
Psoriasis susceptibility 8
Psoriasis susceptibility 9

References:

1.

Veal CD et al. (2001) Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS1 and candidate loci.

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2.

Parham C et al. (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.

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3.

Kauffman CL et al. (2004) A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis.

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4.

Cargill M et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

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5.

Capon F et al. (2007) Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

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6.

Hüffmeier U et al. (2009) Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.

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7.

Nair RP et al. (2009) Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

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Update: Aug. 14, 2020
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