Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Susceptibility to mycobacterial diseases

Genetic susceptibility to mycobacterial diseases is a condition caused by variants of the TIRAP gene.

Systematic

Disposition to infections
Disorders of mRNA editing
Familial candidiasis
Genetic susceptibility to aspergillosis
HIV resistance
IRAK4 deficiency
Invasive pneumococcal disease
Measles infection susceptibility
Meningococcal infection susceptibility
Resistance to trypanosoma brucei
Septic shock
Susceptibility to bacteremia 1
Susceptibility to malaria
Susceptibility to mycobacterial diseases
TIRAP
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
IKBKG
Susceptibility to pseudomonas infection
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency

References:

1.

Thye T et al. (2009) MCP-1 promoter variant -362C associated with protection from pulmonary tuberculosis in Ghana, West Africa.

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2.

Tailleux L et al. (2003) DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.

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3.

Mitsos LM et al. (2003) Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs.

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4.

Jamieson SE et al. (2004) Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians.

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5.

Miller EN et al. (2004) Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians.

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6.

Ozbek N et al. (2005) Interleukin-12 receptor beta 1 chain deficiency in a child with disseminated tuberculosis.

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7.

Tailleux L et al. (2005) DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis.

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8.

Malik S et al. (2006) Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia.

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9.

Flores-Villanueva PO et al. (2005) A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.

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10.

Barreiro LB et al. (2006) Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.

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11.

Delgado JC et al. (2006) Aspartic acid homozygosity at codon 57 of HLA-DQ beta is associated with susceptibility to pulmonary tuberculosis in Cambodia.

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12.

Berrington WR et al. (2007) Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter?

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13.

Cooke GS et al. (2008) Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis.

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14.

Geijtenbeek TB et al. (2003) Mycobacteria target DC-SIGN to suppress dendritic cell function.

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15.

Velez DR et al. (2009) NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans.

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16.

Intemann CD et al. (2009) Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.

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17.

Behr M et al. (2010) TB: screening for responses to a vile visitor.

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18.

Tobin DM et al. (2010) The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans.

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19.

Khor CC et al. (2010) CISH and susceptibility to infectious diseases.

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20.

Shah JA et al. (2012) Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.

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21.

Das B et al. (2013) CD271(+) bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis.

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22.

Salie M et al. (2014) Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease.

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23.

Gopal R et al. (2013) S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis.

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24.

Zhang G et al. (2014) Allele-specific induction of IL-1β expression by C/EBPβ and PU.1 contributes to increased tuberculosis susceptibility.

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25.

Kubler A et al. (2016) Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.

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26.

Berg RD et al. (2016) Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration.

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27.

None (1978) Tuberculosis in twins: a re-analysis of the Prophit survey.

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28.

Rossouw M et al. (2003) Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene.

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29.

Cooke GS et al. (2006) Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.

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30.

Søborg C et al. (2003) Mannose-binding lectin polymorphisms in clinical tuberculosis.

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31.

Barnes PF et al. (1990) Local production of tumor necrosis factor and IFN-gamma in tuberculous pleuritis.

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32.

Flynn JL et al. (1995) Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.

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33.

Keane J et al. (2001) Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.

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34.

Roach DR et al. (2002) TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection.

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35.

Stein CM et al. (2005) Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis.

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36.

Ogus AC et al. (2004) The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease.

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37.

Khor CC et al. (2007) A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

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38.

Selvaraj P et al. (2004) Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis.

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39.

Bornman L et al. (2004) Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.

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40.

Stein CM et al. (2007) Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes.

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41.

None (1992) Genetics and resistance to tuberculosis. Could resistance be enhanced by genetic engineering?

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42.

Stead WW et al. (1990) Racial differences in susceptibility to infection by Mycobacterium tuberculosis.

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43.

Goldfeld AE et al. (1998) Association of an HLA-DQ allele with clinical tuberculosis.

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44.

Bellamy R et al. (1998) Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.

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45.

Bellamy R et al. (1999) Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene.

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46.

Bellamy R et al. (2000) Genetic susceptibility to tuberculosis in Africans: a genome-wide scan.

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47.

Abel L et al. (2000) Genetic predisposition to clinical tuberculosis: bridging the gap between simple and complex inheritance.

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48.

Floros J et al. (2000) Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population.

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49.

Price NM et al. (2001) Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo.

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50.

Casanova JL et al. (2002) Genetic dissection of immunity to mycobacteria: the human model.

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51.

Cervino AC et al. (2002) Fine mapping of a putative tuberculosis-susceptibility locus on chromosome 15q11-13 in African families.

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