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Multiple self-healing palmoplantar carcinoma

Multiple self-healing palmoplantar carcinomata is an autosomal dominant disorder caused by mutations of the NLRP1 gene.

Systematic

Hereditary tumors
Capillary infantile hemangioma
Carcinoid tumor of lung
Gastric cancer
Hereditary brain tumors
Hereditary malign blood disorders
Hereditary renal tumors
Lymphangiomyomatosis
Multiple self-healing palmoplantar carcinoma
NLRP1
Neurofibromatosis
Susceptibility to Kaposi sarcoma
lipoma

References:

1.

Soler VJ et. al. (2013) Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis.

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2.

Mama et. al. (2015) Multiple self-healing palmoplantar carcinoma: a familial predisposition to skin cancer with primary palmoplantar and conjunctival lesions.

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3.

Zhong FL et. al. (2016) Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation.

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Update: Aug. 14, 2020
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