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Atopy

Atopy is an inborn allergic reaction mediated by immunoglobulin E. It may accur on all surfaces that come into contact with the allergogenic substance (skin, gastro intestinal tract, respiratory tract).

Systematic

Hereditary immunological disorders
Atopy
MS4A2
Autoimmune disease
Autoinflammatory disease
Chediak-Higashi syndrome
Graft-versus-host disease protection
Griscelli syndrome type 2
Hereditary complement disorders
Immunoglobulin disorders
Interferonopathy
Primary immunodeficiency
Susceptibility to allergic rhinitis
Susceptibility to asthma

References:

1.

Collée JM et al. (1993) Allele sharing on chromosome 11q13 in sibs with asthma and atopy.

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2.

Cookson WO et al. (1988) Dominant inheritance of atopic immunoglobulin-E responsiveness.

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3.

Jeffreys AJ et al. () Hypervariable 'minisatellite' regions in human DNA.

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4.

Marsh DG et al. (1974) Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity.

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5.

Morton NE et al. (1974) Analysis of family resemblance. 3. Complex segregation of quantitative traits.

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6.

None (1972) Emperic risks for genetic counseling in families with allergy.

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7.

Meyers DA et al. (1983) The inheritance of immunoglobulin E: genetic linkage analysis.

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8.

Hasstedt SJ et al. (1983) Inheritance of immunoglobulin E: genetic model fitting.

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9.

Blumenthal MN et al. (1981) Genetic transmission of serum IgE Levels.

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10.

Rao DC et al. (1980) Immunoglobulin E revisited.

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11.

Shirakawa T et al. (1994) Linkage between severe atopy and chromosome 11q13 in Japanese families.

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12.

Coleman R et al. (1993) Chromosome 11q13 and atopy underlying atopic eczema.

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13.

Sandford AJ et al. (1993) Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.

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14.

Kimura K et al. (1999) Linkage and association of atopic asthma to markers on chromosome 13 in the Japanese population.

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15.

Oettgen HC et al. (1999) IgE in asthma and atopy: cellular and molecular connections.

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16.

Milgrom H et al. (1999) Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group.

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17.

Wheatley AP et al. (2002) Identification of the autoantigen SART-1 as a candidate gene for the development of atopy.

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18.

Hargrave S et al. (2003) Preliminary findings in corneal allograft rejection in patients with keratoconus.

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19.

Hecker M et al. (2003) Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females.

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20.

None (1954) A study of the inheritance of atopic hypersensitivity in man.

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21.

None (1960) Prurigo Besnier (atopic dermatitis) with special reference to the role of allergic factors. I. The influence of atopic hereditary factors.

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22.

Sharma S et al. (2005) A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels.

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23.

Mathias RA et al. (2005) Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses.

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24.

Hanson B et al. (1991) Atopic disease and immunoglobulin E in twins reared apart and together.

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25.

Hizawa N et al. (1995) Association between high serum total IgE levels and D11S97 on chromosome 11q13 in Japanese subjects.

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26.

Shin HD et al. (2004) Association of tumor necrosis factor polymorphisms with asthma and serum total IgE.

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27.

Lympany P et al. (1992) Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine.

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28.

Amelung PJ et al. (1992) Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p.

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29.

Palmer LJ et al. (2000) Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families.

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30.

Moffatt MF et al. (2001) Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample.

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31.

Anderson GG et al. (2002) Positive association to IgE levels and a physical map of the 13q14 atopy locus.

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32.

Zhang Y et al. (2003) Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.

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33.

Shin HD et al. (2003) Association of Eotaxin gene family with asthma and serum total IgE.

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34.

Hysi P et al. (2005) NOD1 variation, immunoglobulin E and asthma.

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35.

Bottazzo GF et al. (1976) Separate autoantibodies to human pancreatic glucagon and somatostatin cells.

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36.

Gerrard JW et al. (1978) A genetic study of immunoglobulin E.

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37.

Marsh DG et al. (1992) A major gene for allergy--fact or fancy?

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38.

Cookson WO et al. (1992) Maternal inheritance of atopic IgE responsiveness on chromosome 11q.

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39.

None (1992) John Bostock, hay fever, and the mechanism of allergy.

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40.

Lympany P et al. (1992) Genetic analysis of the linkage between chromosome 11q and atopy.

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41.

Moffatt MF et al. (1992) Factors confounding genetic linkage between atopy and chromosome 11q.

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42.

Hizawa N et al. (1992) Lack of linkage between atopy and locus 11q13.

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43.

Rich SS et al. (1992) Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97.

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44.

None (1992) Genetic linkage: interpreting lod scores.

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45.

Young RP et al. (1992) Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13.

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46.

Cookson WO et al. (1989) Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q.

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47.

OMIM.ORG article

Omim 147050 external link
48.

Wikipedia article

Wikipedia EN (Atopy) external link
Update: Aug. 14, 2020
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