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Ligneous conjunctivitis

Conjunctivitis lignosa is an autosoml recessive disorder caused by mutations of the PLG gene and the resulting hypoplasminogenemia. The chronic conjunctivitis is characterized by pseudomembranes.

Systematic

Hereditary ocular disease and visual impairment
Aplasia of lacrimal and salivary glands
Chediak-Higashi syndrome
Fish-eye disease
Hereditary glaucoma
IVIC syndrome
Knobloch syndrome 1
Lacrimoauriculodentodigital syndrome
Ligneous conjunctivitis
PLG
Macular degeneration
Manitoba oculotrichoanal syndrome
Papillorenal syndrome
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
Retinitis pigmentosa
Syndromic microphthalmia 6
Usher syndrome

References:

1.

Shigekiyo T et al. (1992) Type I congenital plasminogen deficiency is not a risk factor for thrombosis.

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2.

Mingers AM et al. (1997) Homozygous type I plasminogen deficiency.

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3.

Ramsey DT et al. () Ligneous conjunctivitis in four Doberman pinschers.

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4.

Nüssgens Z et al. (1993) Ligneous conjunctivitis. Ten years follow-up.

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5.

Marcus DM et al. (1990) Ligneous conjunctivitis with ear involvement.

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6.

Tefs K et al. (2006) Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.

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7.

Schuster V et al. () Ligneous conjunctivitis.

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8.

Schuster V et al. (1999) Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.

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9.

Schott D et al. (1998) Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.

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10.

Kao WW et al. (1998) Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.

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11.

Drew AF et al. (1998) Ligneous conjunctivitis in plasminogen-deficient mice.

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12.

Schuster V et al. (1997) Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

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13.

Tait RC et al. (1996) Isolated familial plasminogen deficiency may not be a risk factor for thrombosis.

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14.

Bateman JB et al. () Ligneous conjunctivitis: an autosomal recessive disorder.

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15.

Dolan G et al. (1988) Thrombovascular disease and familial plasminogen deficiency: a report of three kindreds.

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16.

None (1990) Ligneous conjunctivitis: an ophthalmic disease with potentially fatal tracheobronchial obstruction. Laryngeal and tracheobronchial features.

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17.

Aoki N et al. (1978) Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.

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18.

OMIM.ORG article

Omim 217090 external link
19.

Orphanet article

Orphanet ID 97231 external link
20.

Wikipedia article

Wikipedia EN (Ligneous_conjunctivitis) external link
Update: Aug. 14, 2020
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