Genetically determined juvenile obesity is caused by mutations of the POMC and NR0B2 genes. Inheritance pattern is dominant.
![]() |
||||
![]() |
![]() |
|||
![]() |
![]() |
|||
![]() |
![]() |
|||
![]() |
![]() |
![]() ![]() |
||
![]() |
![]() |
![]() ![]() |
||
![]() |
![]() |
|||
![]() |
![]() |
|||
![]() |
![]() |
|||
![]() |
![]() |
|||
![]() |
![]() |
![]() |
![]() |
![]() |
1. |
Ley RE et al. (2006) Microbial ecology: human gut microbes associated with obesity. ![]() |
2. |
Barsh GS et al. (2000) Genetics of body-weight regulation. ![]() |
3. |
Lowell BB et al. (2000) Towards a molecular understanding of adaptive thermogenesis. ![]() |
4. |
Dong C et al. (2003) Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity. ![]() |
5. |
Schadt EE et al. (2003) Genetics of gene expression surveyed in maize, mouse and man. ![]() |
6. |
Stenson PD et al. (2003) Human Gene Mutation Database (HGMD): 2003 update. ![]() |
7. |
None (2003) Genetic medicine and obesity. ![]() |
8. |
Ozcan U et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. ![]() |
9. |
Osawa M et al. (2005) Association of alpha2-HS glycoprotein (AHSG, fetuin-A) polymorphism with AHSG and phosphate serum levels. ![]() |
10. |
Dong C et al. (2005) Possible genomic imprinting of three human obesity-related genetic loci. ![]() |
11. |
Bell CG et al. (2005) The genetics of human obesity. ![]() |
12. |
Lavebratt C et al. (2005) AHSG gene variant is associated with leanness among Swedish men. ![]() |
13. |
Sina M et al. (1999) Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. ![]() |
14. |
Turnbaugh PJ et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. ![]() |
15. |
Kryukov GV et al. (2007) Most rare missense alleles are deleterious in humans: implications for complex disease and association studies. ![]() |
16. |
Ahituv N et al. (2007) Medical sequencing at the extremes of human body mass. ![]() |
17. |
Barness LA et al. (2007) Obesity: genetic, molecular, and environmental aspects. ![]() |
18. |
Bera TK et al. (2008) A model for obesity and gigantism due to disruption of the Ankrd26 gene. ![]() |
19. |
Chen Y et al. (2008) Variations in DNA elucidate molecular networks that cause disease. ![]() |
20. |
Spalding KL et al. (2008) Dynamics of fat cell turnover in humans. ![]() |
21. |
Qi L et al. (2008) The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. ![]() |
22. |
Calton MA et al. (2009) Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. ![]() |
23. |
Renström F et al. (2009) Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. ![]() |
24. |
Yang X et al. (2009) Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. ![]() |
25. |
Paganini-Hill A et al. (1981) The S-leut anthropometric traits: genetic analysis. ![]() |
26. |
Bahary N et al. (1991) Molecular genetic linkage maps of mouse chromosomes 4 and 6. ![]() |
27. |
Dubern B et al. (2001) Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. ![]() |
28. |
Farooqi IS et al. (2003) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. ![]() |
29. |
Branson R et al. (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. ![]() |
30. |
List JF et al. (2003) Defective melanocortin 4 receptors in hyperphagia and morbid obesity. ![]() |
31. |
Hebebrand J et al. (2004) Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. ![]() |
32. |
Chambers JC et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. ![]() |
33. |
Loos RJ et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. ![]() |
34. |
Willer CJ et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. ![]() |
35. |
Jones JM et al. (1992) Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7. ![]() |
36. |
Perry CA et al. (2008) Predisposition to late-onset obesity in GIRK4 knockout mice. ![]() |
37. |
Nishigori H et al. (2001) Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. ![]() |
38. |
Andersen G et al. (2005) Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. ![]() |
39. |
Meyre D et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. ![]() |
40. |
Moll PP et al. (1991) The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study. ![]() |
41. |
Bahary N et al. (1990) Molecular mapping of the mouse db mutation. ![]() |
42. |
Bouchard C et al. (1990) The response to long-term overfeeding in identical twins. ![]() |
43. |
Hasstedt SJ et al. (1989) Recessive inheritance of a relative fat pattern. ![]() |
44. |
Roberts SB et al. (1988) Energy expenditure and intake in infants born to lean and overweight mothers. ![]() |
45. |
Ravussin E et al. (1988) Reduced rate of energy expenditure as a risk factor for body-weight gain. ![]() |
46. |
Zonta LA et al. (1987) Genetic analysis of human obesity in an Italian sample. ![]() |
47. |
Stunkard AJ et al. (1986) An adoption study of human obesity. ![]() |
48. |
Norman RA et al. (1997) Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group. ![]() |
49. |
OMIM.ORG article Omim 601665![]() |