Increased sensitivity or resistance to vitamin K antagonists can be caused by various genetic variations in distinct genes.
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1. |
Wood AW et al. (1974) Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus). ![]() |
2. |
Whitlon DS et al. (1978) Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition. ![]() |
3. |
Greavses JH et al. (1967) Heritable resistance to warfarin in rats. ![]() |
4. |
Lewis RJ et al. (1967) Warfarin resistance. ![]() |
5. |
Pool JG et al. (1968) Warfarin resistance in the rat. ![]() |
6. |
None (1970) The second reported kindred with hereditary resistance to oral anticoagulant drugs. ![]() |
7. |
Vesell ES et al. (1968) Genetic control of dicumarol levels in man. ![]() |
8. |
Alving BM et al. (1985) Hereditary warfarin resistance. Investigation of a rare phenomenon. ![]() |
9. |
Nebert DW et al. () The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. ![]() |
10. |
Takeuchi F et al. (2009) A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. ![]() |
11. |
Borgiani P et al. (2009) CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. ![]() |
12. |
Limdi NA et al. (2008) VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans. ![]() |
13. |
Cooper GM et al. (2008) A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. ![]() |
15. |
Rost S et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. ![]() |
17. |
O'REILLY RA et al. (1964) HEREDITARY TRANSMISSION OF EXCEPTIONAL RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS. THE FIRST REPORTED KINDRED. ![]() |
18. |
Lindberg RL et al. (1992) Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh. ![]() |
19. |
Yuan HY et al. (2005) A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. ![]() |
20. |
Caldwell MD et al. (2008) CYP4F2 genetic variant alters required warfarin dose. ![]() |
21. |
et al. (2009) Estimation of the warfarin dose with clinical and pharmacogenetic data. ![]() |
22. |
Kohn MH et al. (2000) A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans. ![]() |
23. |
Lush IE et al. (1978) Genetic variation between mice in their metabolism of coumarin and its derivatives. ![]() |
24. |
Yamano S et al. (1990) The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. ![]() |
25. |
OMIM.ORG article Omim 122700![]() |