The disorder is caused by a premature stop codon (p.R387X), and is characterized by elevated prorenin plasma levels, which pathophysiological consequences are yet to be determined.
Hypertension | ||||
ACE | ||||
ACE2 | ||||
AGT | ||||
Benign hyperproreninemia | ||||
REN | ||||
Monogenic hypertension | ||||
Preeclampsia | ||||
Salt-sensitive essential hypertension | ||||
VEGFC | ||||
1. |
van Hooft IM et al. (1991) Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents. |
2. |
Villard E et al. (1994) A mutant renin gene in familial elevation of prorenin. |
3. |
OMIM.ORG article Omim 179820 |