Apolipoprotein A4
Das APOA4-Gen kodiert ein Apolipoprotein, welches ein wichtiger Bestandteil von Chylomikronen und der HDL-Partikel ist. Genetische Variationen sind mit familiärer kombinierter Hyperlipidämie assoziiert.
Genstruktur
Das APOA1-APOC3-APOA4 Gen-Cluster weist einen hohen Grad an linkage disequilibrium auf. So können Assoziationen von bestimmten Polymorphismen eines Gens durchaus auch auf Assoziationen mit Polymorphismen in einem der anderen Gene zusammenhängen.
Gentests:
| Forschung |
Untersuchungsmethoden |
Familienuntersuchung |
| Bearbeitungszeit |
5 Tage |
| Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
| 1. |
von Eckardstein A et al. (1992) Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population.
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| 2. |
Cohen RD et al. (1997) Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.
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| 3. |
Duverger N et al. (1996) Protection against atherogenesis in mice mediated by human apolipoprotein A-IV.
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| 4. |
Menzel HJ et al. (1982) Apolipoprotein A-IV polymorphism in man.
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| 5. |
Green PH et al. (1980) Human apolipoprotein A-IV. Intestinal origin and distribution in plasma.
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| 6. |
Schamaun O et al. (1984) The two apolipoprotein loci apo A-I and apo A-IV are closely linked in man.
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| 7. |
Tracy RP et al. (1982) Two-dimensional gel electrophoresis of serum specimens from a normal population.
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| 8. |
None (1985) Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes.
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| 9. |
Kamboh MI et al. (1987) Genetic studies of human apolipoproteins. I. Polymorphism of apolipoprotein A-IV.
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| 10. |
Menzel HJ et al. (1988) Human apolipoprotein A-IV polymorphism: frequency and effect on lipid and lipoprotein levels.
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| 11. |
Elshourbagy NA et al. (1986) The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III.
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| 12. |
Elshourbagy NA et al. (1987) Structure and expression of the human apolipoprotein A-IV gene.
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| 13. |
Rogne S et al. (1986) Confirmation of the close linkage between the loci for human apolipoproteins AI and AIV by the use of a cloned cDNA probe and two restriction site polymorphisms.
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| 14. |
Lohse P et al. (1990) Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene.
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| 15. |
Menzel HJ et al. (1990) Frequency and effect of human apolipoprotein A-IV polymorphism on lipid and lipoprotein levels in an Icelandic population.
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| 16. |
Lohse P et al. (1990) Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1.
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| 17. |
Kamboh MI et al. (1992) Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism.
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| 18. |
Karathanasis SK et al. (1986) Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4).
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| 19. |
NCBI article
NCBI 337
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| 20. |
OMIM.ORG article
Omim 107690
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Update: 23. Juni 2025