NIMA-Kinas 8

Liu S et al. (2002) A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.

Otto EA et al. (2008) NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis.

Hoff S et al. (2013) ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.

Bowers AJ et al. (2004) Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.

Valkova N et al. (2005) Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice.

Sohara E et al. (2008) Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.

Habbig S et al. (2012) The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.

Manning DK et al. (2013) Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.

Frank V et al. (2013) Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression.

NCBI article

OMIM.ORG article

Orphanet article