Die Veranlagung für Psoriasis lässt sich an verschiedenen Loci des Genoms festmachen. Der Typ 11 ist mit 5q31.1-q33.1 verbunden.
1. |
Zhang XJ et al. (2009) Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. |
2. |
Kauffman CL et al. (2004) A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. |
3. |
Cargill M et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. |
4. |
Capon F et al. (2007) Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. |
5. |
Hüffmeier U et al. (2009) Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis. |
6. |
Nair RP et al. (2009) Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. |
7. |
Tsunemi Y et al. (2002) Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris. |