Die genetisch bedingte Neigung zu nächtlichem Asthma wird durch Mutationen im ADRB2-Gen bestimmt. Die Vererbung folgt dem dominanten Model.
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Morahan G et al. (2002) Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. |
2. |
Lee JJ et al. (2004) Defining a link with asthma in mice congenitally deficient in eosinophils. |
3. |
Huang JL et al. (2004) Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. |
4. |
Randolph AG et al. (2004) The IL12B gene is associated with asthma. |
6. |
Raby BA et al. (2003) Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes. |
7. |
Shin HD et al. (2003) Association of Eotaxin gene family with asthma and serum total IgE. |
8. |
Zhang Y et al. (2003) Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. |
9. |
Kwak YG et al. (2003) Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma. |
10. |
Akbari O et al. (2003) Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. |
11. |
Huang SK et al. (2003) Evidence for asthma susceptibility genes on chromosome 11 in an African-American population. |
12. |
Humbles AA et al. (2004) A critical role for eosinophils in allergic airways remodeling. |
13. |
Hakonarson H et al. (2002) A major susceptibility gene for asthma maps to chromosome 14q24. |
14. |
Van Eerdewegh P et al. (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. |
15. |
Illig T et al. (2002) Genetics of asthma and related phenotypes. |
16. |
Yu C et al. (2002) Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. |
17. |
Anderson GG et al. (2002) Positive association to IgE levels and a physical map of the 13q14 atopy locus. |
18. |
Leaves NI et al. (2002) A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus. |
19. |
Duetsch G et al. (2002) STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study. |
20. |
Niimi T et al. (2002) A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. |
21. |
Dizier MH et al. (2001) Indication of linkage and genetic heterogeneity of asthma according to age at onset on chromosome 7q in 107 French EGEA families. |
22. |
Shum BO et al. (2006) The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. |
23. |
Palmer LJ et al. (2001) Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region. |
24. |
Moffatt MF et al. (2010) A large-scale, consortium-based genomewide association study of asthma. |
25. |
Sleiman PM et al. (2010) Variants of DENND1B associated with asthma in children. |
26. |
Murphy A et al. (2009) PRKCA: a positional candidate gene for body mass index and asthma. |
27. |
Seibold MA et al. (2008) An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity. |
28. |
Xiang YY et al. (2007) A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. |
29. |
Balaci L et al. (2007) IRAK-M is involved in the pathogenesis of early-onset persistent asthma. |
30. |
Batra J et al. (2007) A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels. |
31. |
Levy BD et al. (2007) Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. |
32. |
Celedón JC et al. (2007) Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica. |
33. |
None (1997) A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). |
34. |
Rousseau K et al. (2006) MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function. |
35. |
Pillai SG et al. (2006) A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p. |
36. |
Millstein J et al. (2006) A testing framework for identifying susceptibility genes in the presence of epistasis. |
37. |
Hallstrand TS et al. (2005) Genetic pleiotropy between asthma and obesity in a community-based sample of twins. |
38. |
Que LG et al. (2005) Protection from experimental asthma by an endogenous bronchodilator. |
39. |
Hoffjan S et al. (2005) Gene-environment interaction effects on the development of immune responses in the 1st year of life. |
40. |
Hysi P et al. (2005) NOD1 variation, immunoglobulin E and asthma. |
41. |
Hao K et al. (2005) Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness. |
42. |
Nicolae D et al. (2005) Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. |
43. |
Aoki T et al. (2006) An association between asthma and TNF-308G/A polymorphism: meta-analysis. |
44. |
Marsh DG et al. (1994) Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. |
45. |
Postma DS et al. (1995) Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. |
46. |
De Sanctis GT et al. (1995) Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. |
47. |
Hirshman CA et al. (1984) Airway responses in offspring of dogs with and without airway hyperreactivity. |
48. |
Townley RG et al. (1986) Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma. |
49. |
Longo G et al. (1987) Genetic factors in nonspecific bronchial hyperreactivity. An epidemiologic study. |
50. |
Levitt RC et al. (1988) Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice. |
51. |
Levitt RC et al. (1989) Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine. |
52. |
Amelung PJ et al. (1992) Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p. |
53. |
Lympany P et al. (1992) Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine. |
54. |
Xu X et al. (2001) A genomewide search for quantitative-trait loci underlying asthma. |
55. |
Shin HD et al. (2004) Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. |
56. |
Witte JS et al. (2002) Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma. |
57. |
Howard TD et al. (2002) Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. |
58. |
Howard TD et al. (2001) Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. |
59. |
Heinzmann A et al. (2000) Genetic variants of IL-13 signalling and human asthma and atopy. |
60. |
Karp CL et al. (2000) Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. |
61. |
Wjst M et al. (1999) A genome-wide search for linkage to asthma. German Asthma Genetics Group. |
62. |
Ober C et al. (1998) Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. |
63. |
Gavett SH et al. (1995) Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. |
64. |
Gleich GJ et al. (1997) Bronchial asthma: lessons from murine models. |
65. |
McIntire JJ et al. (2001) Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. |
66. |
Kirkbride HJ et al. (2001) Genetic polymorphism of MUC7: allele frequencies and association with asthma. |
67. |
Moffatt MF et al. (2001) Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. |
68. |
Xu J et al. (2001) Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. |
69. |
Laitinen T et al. (2001) A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. |
71. |
Palmer LJ et al. (2000) Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families. |
72. |
Ober C et al. (2000) A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. |
74. |
Humbles AA et al. (2000) A role for the C3a anaphylatoxin receptor in the effector phase of asthma. |
75. |
Yokouchi Y et al. (2000) Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. |
76. |
Kruse S et al. (2000) The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. |
77. |
Matsuoka T et al. (2000) Prostaglandin D2 as a mediator of allergic asthma. |
78. |
Symula DJ et al. (1999) Functional screening of an asthma QTL in YAC transgenic mice. |
79. |
Wilkinson J et al. (1998) Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores. |
80. |
Holroyd KJ et al. (1998) Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. |
81. |
Noguchi E et al. (1997) Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population. |
82. |
Nicolaides NC et al. (1997) Interleukin 9: a candidate gene for asthma. |
83. |
None (1997) Asthma genetics: waiting to exhale. |
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OMIM.ORG article Omim 600807 |