Das Hypernephrom ist eine bösartige Nierenerkrankung, die sich histologisch durch klarzellige Carcinomzellen auszeichnet. Meist sind es somatische Mutationen, die ein solches Carcinom auslösen. Wenn allerdings solche Carcinome an verschiedenen Stellen und beidseitig auftreten sollte auch an Keimbahnmutationen in den genannten Genen gedacht werden. Die Vererbung ist dominant allerdings mit unterschiedlicher Penetranz.
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OMIM.ORG article Omim 144700 |
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Wikipedia Artikel Wikipedia DE (Nierenkrebs) |