Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Renal insufficiency

Chronic renal failure is develops based on progressive renal damage that results in reduction of the glomerular filtration rate. At its final stage, requires renal replacement therapy (dialysis or transplantation).


Apparent mineralocorticoid excess
Protracted hyperkalemia and nephrocalcinosis lead to chronic renal failure.
95% of patient with cystinosis develop renal failure. It starts with 8-12 years of age.
Dent disease
Up to 80% of male patients reach end-stage renal failure in their 30-50th decade. Cause is progressive nephrocalcinosis and complications of recurrent nephrolithiasis.
ATTR amyloidosis
Though renal insufficiency may develop due to renal involvement, this condition will rarely dominate the clinical picture.
Update: Aug. 14, 2020
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