Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The TRAP1 gene encodes a mitochondrial heat shock protein 75 kDa. It interacts mit tumor necrosis factor type 1 and is involves in intracellular stress response.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Standing AS et al. (2020) TRAP1 chaperone protein mutations and autoinflammation. 
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| 2. |
Song HY et al. (1995) Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
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| 3. |
Chen CF et al. (1996) A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock.
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| 4. |
Raskind WH et al. (1998) Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostoses.
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| 5. |
Simmons AD et al. (1999) A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses.
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| 6. |
Felts SJ et al. (2000) The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.
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| 7. |
Chen B et al. (2005) The HSP90 family of genes in the human genome: insights into their divergence and evolution.
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