Interleukin-4

Horsley V et al. (2003) IL-4 acts as a myoblast recruitment factor during mammalian muscle growth.

Saltman DL et al. (1993) A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization.

Kotanides H et al. (1996) Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene.

Kawashima T et al. (1998) Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.

Dickensheets HL et al. (1999) Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

Hunt PJ et al. (2000) Cytokine gene polymorphisms in autoimmune thyroid disease.

Carvalho LH et al. (2002) IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

Inoue T et al. (2002) Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis.

Ozaki K et al. (2002) A critical role for IL-21 in regulating immunoglobulin production.

Ghoreschi K et al. (2003) Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.

Messi M et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes.

Zavros Y et al. (2003) Treatment of Helicobacter gastritis with IL-4 requires somatostatin.

Zee RY et al. (2004) Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.

Nguyen KD et al. (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

Vijayanand P et al. (2012) Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V.

Harada Y et al. (2012) The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells.

Reese TA et al. (2014) Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.

Osborne LC et al. (2014) Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.

Minutti CM et al. (2017) Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver.

Leung DY et al. (1988) Clinical and immunologic aspects of the hyperimmunoglobulin E syndrome.

Fields PE et al. (2002) Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation.

Spilianakis CG et al. (2005) Interchromosomal associations between alternatively expressed loci.

Sutherland GR et al. (1988) Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.

Smirnov DV et al. (1995) Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.

Loots GG et al. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

Lacy DA et al. (2000) Faithful expression of the human 5q31 cytokine cluster in transgenic mice.

Kelly-Welch AE et al. (2003) Interleukin-4 and interleukin-13 signaling connections maps.

LaPorte SL et al. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

Wu D et al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.

Bosurgi L et al. (2017) Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.

Le Beau MM et al. (1993) Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.

Arai N et al. (1989) Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.

Takahashi M et al. (1989) Chromosomal mapping of the mouse IL-4 and human IL-5 genes.

Le Beau MM et al. (1989) Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q).

Yokota T et al. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

Eder A et al. (1988) The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.

Lewis DB et al. (1993) Osteoporosis induced in mice by overproduction of interleukin 4.

NCBI article

OMIM.ORG article

Wikipedia article