Tight junction protein ZO-1
The TJP1 gene encodes a tight junction protein. In animal experiments, double knock-out mice are lethal. In humans no disease is associated to this gene yet.
Genetests:
Related Diseases:
References:
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Willott E et al. (1992) Localization and differential expression of two isoforms of the tight junction protein ZO-1.
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Balda MS et al. (1993) Two classes of tight junctions are revealed by ZO-1 isoforms.
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Willott E et al. (1993) The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
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Mohandas TK et al. (1995) Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7.
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Itoh M et al. (1999) Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.
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D'Atri F et al. (2002) Evidence for a functional interaction between cingulin and ZO-1 in cultured cells.
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Amieva MR et al. (2003) Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA.
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Nielsen PA et al. (2003) Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1).
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Tang Y et al. (2008) Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease.
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Katsuno T et al. (2008) Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.
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Huo L et al. (2011) Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.
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NCBI article
NCBI 7082
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OMIM.ORG article
Omim 601009
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Wikipedia article
Wikipedia EN (Tight_junction_protein_1)
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Update: Aug. 14, 2020