Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Das TRAP1-Gen kodiert ein 75 kDa mitochondriales Heat-Shock-Protein, welches mit dem Tumor-Nekrose-Faktor 1 interagiert und für die intrazelluläre Stressantwort verantwortlich ist.
| Klinisch | Untersuchungsmethoden | Familienuntersuchung |
| Bearbeitungszeit | 5 Tage | |
| Probentyp | genomische DNS |
| Forschung | Untersuchungsmethoden | Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| 1. |
Standing AS et al. (2020) TRAP1 chaperone protein mutations and autoinflammation. 
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| 2. |
Song HY et al. (1995) Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
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| 3. |
Chen CF et al. (1996) A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock.
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| 4. |
Raskind WH et al. (1998) Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostoses.
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| 5. |
Simmons AD et al. (1999) A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses.
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| 6. |
Felts SJ et al. (2000) The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.
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| 7. |
Chen B et al. (2005) The HSP90 family of genes in the human genome: insights into their divergence and evolution.
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