Chronic renal failure is develops based on progressive renal damage that results in reduction of the glomerular filtration rate. At its final stage, requires renal replacement therapy (dialysis or transplantation).
Apparent mineralocorticoid excess | |
Protracted hyperkalemia and nephrocalcinosis lead to chronic renal failure. |
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Cystinosis | |
95% of patient with cystinosis develop renal failure. It starts with 8-12 years of age. |
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Dent disease | |
Up to 80% of male patients reach end-stage renal failure in their 30-50th decade. Cause is progressive nephrocalcinosis and complications of recurrent nephrolithiasis. |
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ATTR amyloidosis | |
Though renal insufficiency may develop due to renal involvement, this condition will rarely dominate the clinical picture. |