Agouti-related protein
The AGRP gene encodes a protein that is involved in signal transduction from melanocortin-3 and melanocortin-4 receptors. Mutations cause autosomal dominant late onset obesity or leanness.
Genetests:
Related Diseases:
References:
1. |
Kitamura T et al. (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.
|
2. |
Shutter JR et al. (1997) Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.
|
3. |
Ollmann MM et al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.
|
4. |
Graham M et al. (1997) Overexpression of Agrt leads to obesity in transgenic mice.
|
5. |
Katsuki A et al. (2001) Plasma levels of agouti-related protein are increased in obese men.
|
6. |
Brown AM et al. (2001) The gene structure and minimal promoter of the human agouti related protein.
|
7. |
Argyropoulos G et al. (2002) A polymorphism in the human agouti-related protein is associated with late-onset obesity.
|
8. |
Marks DL et al. (2004) Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.
|
9. |
Luquet S et al. (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.
|
10. |
Andrews ZB et al. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
|
11. |
Atasoy D et al. (2012) Deconstruction of a neural circuit for hunger.
|
12. |
Krashes MJ et al. (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.
|
13. |
OMIM.ORG article
Omim 602311
|
14. |
NCBI article
NCBI 181
|
15. |
Wikipedia article
Wikipedia EN (Agouti-related_peptide)
|
Update: Aug. 14, 2020