Vitamin K-dependent protein Z
The PROZ gene encodes protein Z, a regulator of the coagulation system which together with cofactor encoded by the SERPINA10 gene inhibits activated coagulations factors Xa and XIa. Inactivating mutations may promote thrombophilia.
Genetests:
Related Diseases:
References:
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Vasse M et al. (2001) Frequency of protein Z deficiency in patients with ischaemic stroke.
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Kemkes-Matthes B et al. (2005) R255h amino acid substitution of protein Z identified in patients with factor V Leiden mutation.
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Han X et al. (1998) Isolation of a protein Z-dependent plasma protease inhibitor.
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4. |
Fujimaki K et al. (1998) The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon.
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Højrup P et al. (1982) Amino-acid sequence of the vitamin-K-dependent part of protein Z.
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6. |
Broze GJ et al. (1984) Human Protein Z.
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7. |
Højrup P et al. (1985) Amino acid sequence of bovine protein Z: a vitamin K-dependent serine protease homolog.
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8. |
Ichinose A et al. (1990) Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein.
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9. |
Hogg PJ et al. (1991) Interaction of human protein Z with thrombin: evaluation of the species difference in the interaction between bovine and human protein Z and thrombin.
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Prowse CV et al. (1977) The isolation of a new warfarin-sensitive protein from bovine plasma.
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Santacroce R et al. (2006) Low protein Z levels and risk of occurrence of deep vein thrombosis.
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12. |
Souri M et al. (2005) A naturally occurring E30Q mutation in the Gla domain of protein Z causes its impaired secretion and subsequent deficiency.
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13. |
Lichy C et al. (2004) A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young.
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14. |
None (2001) Protein Z-dependent regulation of coagulation.
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15. |
Yin ZF et al. (2000) Prothrombotic phenotype of protein Z deficiency.
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Orphanet article
Orphanet ID 391022
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NCBI article
NCBI 8858
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OMIM.ORG article
Omim 176895
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19. |
Wikipedia article
Wikipedia EN (Protein_Z)
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Update: Aug. 14, 2020