Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The CXCR1 gene encodes a chemokine receptor for interleukin 8. Genetic variations influence susceptibility to HIV infections and disease progression. Also in animal models a mesangioproliferative glomerulonephritis was observed.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
HIV resistance
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AIDS progression
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IFNG
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CCR5
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CXCR1
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HIV-1 viremia susceptibility
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HLA-C
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HIV1 susceptibility
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IL10
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| 1. |
Morris SW et al. (1992) Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. 
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| 2. |
Holmes WE et al. (1991) Structure and functional expression of a human interleukin-8 receptor.
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| 3. |
Mollereau C et al. (1993) The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor.
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| 4. |
Lloyd A et al. (1993) Assignment of genes for interleukin-8 receptors (IL8R) A and B to human chromosome band 2q35.
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| 5. |
Palter SF et al. (2001) Interleukin-8 in the human fallopian tube.
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| 6. |
Weathington NM et al. (2006) A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.
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| 7. |
Vasilescu A et al. (2007) A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.
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| 8. |
Hartl D et al. (2007) Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease.
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| 9. |
Ozaltin F et al. (2013) Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.
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| 10. |
NCBI article NCBI 3577
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| 11. |
OMIM.ORG article Omim 146929
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| 12. |
Wikipedia article Wikipedia EN (Interleukin_8_receptor,_alpha)
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